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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Themis+
wild type
MGI:3839022
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		ThemisSpotr/Themis+ C57BL/6-ThemisSpotr MGI:4359659
ht2
 		Themistm1.1Hko/Themis+ Not Specified MGI:4359661
ht3
 		Themistm1Hasu/Themis+ involves: C57BL/6 * CBA MGI:4365448


Genotype
MGI:4359659
ht1
Allelic
Composition		 ThemisSpotr/Themis+
Genetic
Background		 C57BL/6-ThemisSpotr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ThemisSpotr mutation (0 available); any Themis mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD4-positive, alpha-beta T cell number ( J:152601 )
• CD4+ T cell numbers are significantly reduced in the periphery
decreased CD8-positive, alpha-beta T cell number ( J:152601 )
• CD8+ T cell numbers are significantly reduced in the periphery

hematopoietic system
decreased CD4-positive, alpha-beta T cell number ( J:152601 )
• CD4+ T cell numbers are significantly reduced in the periphery
decreased CD8-positive, alpha-beta T cell number ( J:152601 )
• CD8+ T cell numbers are significantly reduced in the periphery




Genotype
MGI:4359661
ht2
Allelic
Composition		 Themistm1.1Hko/Themis+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Themistm1.1Hko mutation (0 available); any Themis mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD4-positive, alpha-beta T cell number ( J:152601 )
• CD4+ T cell numbers are reduced in the periphery
decreased CD8-positive, alpha-beta T cell number ( J:152601 )
• CD8+ T cell numbers are reduced in the periphery

hematopoietic system
decreased CD4-positive, alpha-beta T cell number ( J:152601 )
• CD4+ T cell numbers are reduced in the periphery
decreased CD8-positive, alpha-beta T cell number ( J:152601 )
• CD8+ T cell numbers are reduced in the periphery




Genotype
MGI:4365448
ht3
Allelic
Composition		 Themistm1Hasu/Themis+
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Themistm1Hasu mutation (0 available); any Themis mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD4-positive, alpha-beta T cell number ( J:153235 )
• mice exhibit an intermediate decrease in thymic CD4+ cells compared to in wild-type mice and homozygotes
decreased CD8-positive, alpha-beta T cell number ( J:153235 )
• mice exhibit an intermediate decrease in thymic CD8+ cells compared to in wild-type mice and homozygotes

hematopoietic system
decreased CD4-positive, alpha-beta T cell number ( J:153235 )
• mice exhibit an intermediate decrease in thymic CD4+ cells compared to in wild-type mice and homozygotes
decreased CD8-positive, alpha-beta T cell number ( J:153235 )
• mice exhibit an intermediate decrease in thymic CD8+ cells compared to in wild-type mice and homozygotes




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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory