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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rxratm1.1Pcn
targeted mutation 1.1, Pierre Chambon
MGI:3839151
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Rxratm1.1Pcn/Rxratm1.1Pcn involves: 129S2/SvPas * C57BL/6 * SJL MGI:3839229
cx2
Rxratm1.1Pcn/Rxratm1.1Pcn
Rxrbtm1Ipc/Rxrbtm1Ipc
involves: 129S2/SvPas * C57BL/6 * SJL MGI:3839231


Genotype
MGI:3839229
hm1
Allelic
Composition
Rxratm1.1Pcn/Rxratm1.1Pcn
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rxratm1.1Pcn mutation (0 available); any Rxra mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice found alive at E18.5 do not survive more than a few hours after birth by Caesarean section

vision/eye
• the ventral portion is thickened at E14.5
• ventral rotation is seen at E14.5
• at E14.5 all mice have a persistent and hyperplasic primary vitreous body
• closer eyelid folds in mice at E14.5
• small optic disc coloboma is seen in 90% of mice at E14.5 but not in any mice at E18.5 suggesting a delay in optic disc formation
• shortened ventral retina at E14.5
• agenesis of the sclera is seen in all mice at E18.5

cardiovascular system
• seen in 1 of 10 mice at E14.5 but not in any mice at E18.5
• hypoplasia of the compact layer of the ventricular myocardium is seen in 20% (2 of 10) of mice at E14.5 and in 1 of 3 mice at E18.5
• agenesis of the conotruncal septum is seen in 1 of 10 mice at E14.5
• however, no mice show absence of the membranous portion of the ventricular septum at E18.5

digestive/alimentary system
• agenesis of the sublingual gland ducts at E18.5

embryo
• seen in 1 of 10 mice at E14.5 but not in any mice at E18.5
• at E14.5 - E18.5, the boundary between the spongiotrophoblast and labyrinth is ill defined
• at E14.5 - E18.5, labyrinthine trabeculae appear abnormally thick

growth/size/body
• at E18.5 live mice weigh about 1/3 less than controls

endocrine/exocrine glands
• agenesis of the sublingual gland ducts at E18.5

nervous system
• small optic disc coloboma is seen in 90% of mice at E14.5 but not in any mice at E18.5 suggesting a delay in optic disc formation

craniofacial
• seen in 1 of 10 mice at E14.5 but not in any mice at E18.5

muscle
• hypoplasia of the compact layer of the ventricular myocardium is seen in 20% (2 of 10) of mice at E14.5 and in 1 of 3 mice at E18.5




Genotype
MGI:3839231
cx2
Allelic
Composition
Rxratm1.1Pcn/Rxratm1.1Pcn
Rxrbtm1Ipc/Rxrbtm1Ipc
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rxratm1.1Pcn mutation (0 available); any Rxra mutation (30 available)
Rxrbtm1Ipc mutation (0 available); any Rxrb mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
N
• unlike in mice null for both Rxra and Rxrb, placentas appear normal at E10.5
• seen in 4 of 5 embryos at E10.5

growth/size/body
• seen in 4 of 5 embryos at E10.5





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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory