mortality/aging
• deaths start to occur around 2 weeks of age
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growth/size/body
behavior/neurological
• partial and then full tonic-clonic seizures
• ictal episodes sometimes provoke sudden death
• duration of bicuculine induced epileptiform activity in CA3 and intervals between bursts are significantly longer than in controls
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nervous system
• partial and then full tonic-clonic seizures
• ictal episodes sometimes provoke sudden death
• duration of bicuculine induced epileptiform activity in CA3 and intervals between bursts are significantly longer than in controls
|
• paired pulse depression of inhibitory postsynaptic currents is significantly smaller than in controls
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• single shock stimulation in the stratum radiatum area of CA1 in hippocampal slices fails to elicit the slow component of the inhibitory postsynaptic potential
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