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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gabbr2tm1Arca
targeted mutation 1, Andrew R Calver
MGI:3839235
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gabbr2tm1Arca/Gabbr2tm1Arca involves: 129P2/OlaHsd MGI:3839239


Genotype
MGI:3839239
hm1
Allelic
Composition
Gabbr2tm1Arca/Gabbr2tm1Arca
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabbr2tm1Arca mutation (0 available); any Gabbr2 mutation (62 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• deaths start to occur around 2 weeks of age

growth/size/body

behavior/neurological
• conspicuous epileptic phenotype
• partial and then full tonic-clonic seizures
• ictal episodes sometimes provoke sudden death
• duration of bicuculine induced epileptiform activity in CA3 and intervals between bursts are significantly longer than in controls

nervous system
• conspicuous epileptic phenotype
• partial and then full tonic-clonic seizures
• ictal episodes sometimes provoke sudden death
• duration of bicuculine induced epileptiform activity in CA3 and intervals between bursts are significantly longer than in controls
• paired pulse depression of inhibitory postsynaptic currents is significantly smaller than in controls
• single shock stimulation in the stratum radiatum area of CA1 in hippocampal slices fails to elicit the slow component of the inhibitory postsynaptic potential





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory