Phenotypes associated with this allele

• Allele Symbol: Smad3^tm1Sche
• Allele Name: targeted mutation 1, Sheldon Chen
• Allele ID: MGI:3839291
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Smad3^tm1Sche/Smad3^tm1Sche	B6.129P2-Smad3^tm1Sche	MGI:3839292

Genotype
MGI:3839292

hm1

• Allelic Composition: Smad3^tm1Sche/Smad3^tm1Sche
• Genetic Background: B6.129P2-Smad3^tm1Sche

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating creatinine level ( J:145114 )

• streptozotocin-treated mice do not exhibit the increase in plasma creatinine levels observed in similarly treated wild-type mice

decreased blood urea nitrogen level ( J:145114 )

• streptozotocin-treated mice do not exhibit the increase in blood urine nitrogen levels observed in similarly treated wild-type mice

abnormal physiological response to xenobiotic ( J:145114 )

• streptozotocin-treated mice do not exhibit the increase in kidney weight, plasma creatinine levels, blood urine nitrogen levels, and glomerular basement membrane thickening, reduction in body weight, and mesangial expansion observed in similarly treated wild-type mice

• however, streotozotocin-treated mice exhibit hyperglycemia, albuminuria, and reduced slit pore opening as in wild-type mice

renal/urinary system

abnormal renal glomerulus basement membrane thickness ( J:145114 )

• streptozotocin-treated mice do not exhibit the increase in glomerular basement membrane thickening observed in similarly treated wild-type mice

abnormal mesangial matrix morphology ( J:145114 )

• streptozotocin-treated mice do not exhibit the mesangial matrix expansion observed in similarly treated wild-type mice

decreased kidney weight ( J:145114 )

• streptozotocin-treated mice do not exhibit the increase in kidney weight observed in similarly treated wild-type mice

growth/size/body

increased body weight ( J:145114 )

• streptozotocin-treated mice do not exhibit the decreased in body weight observed in similarly treated wild-type mice