Phenotypes associated with this allele

• Allele Symbol: Sohlh2^tm1Rajk
• Allele Name: targeted mutation 1, Aleksandar Rajkovic
• Allele ID: MGI:3839324
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sohlh2^tm1Rajk/Sohlh2^tm1Rajk	involves: 129S7/SvEvBrd * C57BL/6	MGI:3839330

Genotype
MGI:3839330

hm1

• Allelic Composition: Sohlh2^tm1Rajk/Sohlh2^tm1Rajk
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

decreased oocyte number ( J:145802 )

♀ • at 3 weeks of age, ovaries contain few oocytes unlike in wild-type mice

impaired granulosa cell differentiation ( J:145802 )

♀ • granulose cells fail to differentiate from flattened to cuboidal shape as in wild-type mice

abnormal ovarian follicle number ( J:145802 )

♀ • at 3 weeks of age, ovaries contain few ovarian follicles unlike in wild-type mice

decreased primary ovarian follicle number ( J:145802 )

♀ • at P7, mice have few normal primary follicles unlike wild-type mice

♀ • however, primordial follicles are present

ovary atrophy ( J:145802 )

♀ • at 3 weeks of age

female infertility ( J:145802 )

♀

endocrine/exocrine glands

impaired granulosa cell differentiation ( J:145802 )

♀ • granulose cells fail to differentiate from flattened to cuboidal shape as in wild-type mice

abnormal ovarian follicle number ( J:145802 )

♀ • at 3 weeks of age, ovaries contain few ovarian follicles unlike in wild-type mice

decreased primary ovarian follicle number ( J:145802 )

♀ • at P7, mice have few normal primary follicles unlike wild-type mice

♀ • however, primordial follicles are present

ovary atrophy ( J:145802 )

♀ • at 3 weeks of age

cellular

decreased oocyte number ( J:145802 )

♀ • at 3 weeks of age, ovaries contain few oocytes unlike in wild-type mice

impaired granulosa cell differentiation ( J:145802 )

♀ • granulose cells fail to differentiate from flattened to cuboidal shape as in wild-type mice