Phenotypes associated with this allele

• Allele Symbol: Rspo2^tm1Suda
• Allele Name: targeted mutation 1, Toshio Suda
• Allele ID: MGI:3839444
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rspo2^tm1Suda/Rspo2^tm1Suda	B6.Cg-Rspo2^tm1Suda	MGI:3839445

Genotype
MGI:3839445

hm1

• Allelic Composition: Rspo2^tm1Suda/Rspo2^tm1Suda
• Genetic Background: B6.Cg-Rspo2^tm1Suda

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:146829 )

• die within 1 hour of birth

respiratory system

lung hemorrhage ( J:146829 )

• focal hemorrhages are seen in neonates

abnormal laryngeal cartilage morphology ( J:146829 )

arytenoid and cricoid cartilage fusion ( J:146829 )

• fused arytenoid and cricoid cartilages

abnormal lung morphology ( J:146829 )

pulmonary hypoplasia ( J:146829 )

abnormal pulmonary alveolus morphology ( J:146829 )

• decrease in the radial alveolar count

abnormal tracheal cartilage morphology ( J:146829 )

• irregularly shaped and in a disorganized pattern

respiratory failure ( J:146829 )

homeostasis/metabolism

cyanosis ( J:146829 )

• seen in all mice born by C-section at E18.5

limbs/digits/tail

abnormal autopod morphology ( J:146829 )

• 5 and 8 mice are missing over half of the foot on the left and right hindlimbs, respectively

• 10 and 1 mice are missing all of the foot including the heel on the left and right hindlimbs, respectively

hindlimb oligodactyly ( J:146829 )

• 2 and 8 mice are missing some fingers on the left and right hindlimbs, respectively

skeleton

abnormal temporal bone squamous part morphology ( J:146829 )

• mildly deformed

absent mandibular coronoid process ( J:146829 )

abnormal maxilla morphology ( J:146829 )

• severely hypoplastic processes are seen in some mice

maxillary shelf hypoplasia ( J:146829 )

• severely shortened

decreased palatine bone horizontal plate size ( J:146829 )

• slightly reduced in size

abnormal zygomatic bone morphology ( J:146829 )

• mildly deformed

abnormal laryngeal cartilage morphology ( J:146829 )

arytenoid and cricoid cartilage fusion ( J:146829 )

• fused arytenoid and cricoid cartilages

abnormal tracheal cartilage morphology ( J:146829 )

• irregularly shaped and in a disorganized pattern

craniofacial

abnormal temporal bone squamous part morphology ( J:146829 )

• mildly deformed

absent mandibular coronoid process ( J:146829 )

abnormal maxilla morphology ( J:146829 )

• severely hypoplastic processes are seen in some mice

maxillary shelf hypoplasia ( J:146829 )

• severely shortened

decreased palatine bone horizontal plate size ( J:146829 )

• slightly reduced in size

abnormal zygomatic bone morphology ( J:146829 )

• mildly deformed

palatal shelves fail to meet at midline ( J:146829 )

• palatal shelves of mutant mice remain unfused and form a wide cleft in the central fusion line of the palate

cleft upper lip ( J:146829 )

• found in some mice

cleft secondary palate ( J:146829 )

• variable severity

cardiovascular system

lung hemorrhage ( J:146829 )

• focal hemorrhages are seen in neonates

digestive/alimentary system

maxillary shelf hypoplasia ( J:146829 )

• severely shortened

decreased palatine bone horizontal plate size ( J:146829 )

• slightly reduced in size

palatal shelves fail to meet at midline ( J:146829 )

• palatal shelves of mutant mice remain unfused and form a wide cleft in the central fusion line of the palate

cleft secondary palate ( J:146829 )

• variable severity

integument

abnormal nail morphology ( J:146829 )

• frequently lack forelimb nails

growth/size/body

maxillary shelf hypoplasia ( J:146829 )

• severely shortened

decreased palatine bone horizontal plate size ( J:146829 )

• slightly reduced in size

palatal shelves fail to meet at midline ( J:146829 )

• palatal shelves of mutant mice remain unfused and form a wide cleft in the central fusion line of the palate

cleft upper lip ( J:146829 )

• found in some mice

cleft secondary palate ( J:146829 )

• variable severity