About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dkkl1tm1Ducy
targeted mutation 1, Patricia Ducy
MGI:3839561
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dkkl1tm1Ducy/Dkkl1tm1Ducy involves: 129S7/SvEvBrd * C57BL/6J MGI:3839562


Genotype
MGI:3839562
hm1
Allelic
Composition		 Dkkl1tm1Ducy/Dkkl1tm1Ducy
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkkl1tm1Ducy mutation (0 available); any Dkkl1 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal male germ cell apoptosis ( J:146994 )
• spermatocyte apoptosis is decreased compared to in wild-type mice

endocrine/exocrine glands
increased testis weight ( J:146994 )
• in older mice

reproductive system
abnormal male germ cell apoptosis ( J:146994 )
• spermatocyte apoptosis is decreased compared to in wild-type mice
increased testis weight ( J:146994 )
• in older mice
increased sperm number ( J:146994 )
• epididymal sperm count is increased compared to in wild-type mice due to decreased spermatocyte apoptosis
• however, there is no increase in spermatogonia

skeleton
skeleton phenotype ( J:146994 )
N
• skeletogenesis and bone formation are normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory