Phenotypes associated with this allele

• Allele Symbol: Bcl11b^tm1.1Leid
• Allele Name: targeted mutation 1.1, Mark Leid
• Allele ID: MGI:3839576
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Bcl11b^tm1.1Leid/Bcl11b^tm1.1Leid Tg(KRT14-cre)1Ipc/0	involves: C57BL/6 * SJL	MGI:3839579

Genotype
MGI:3839579

cn1

• Allelic Composition: Bcl11b^tm1.1Leid/Bcl11b^tm1.1Leid; Tg(KRT14-cre)1Ipc/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

impaired skin barrier function ( J:147182 )

• delay in skin barrier establishment

• at E17.5 the rate of water loss from the dorsal surface is about 3 fold higher compared to controls but no difference is detected at E18.5

• at E17.5 the rate of water loss from the ventral surface is slightly higher compared to controls and at E18.5 the rate of water loss from the dorsal surface is about 2 to 3 fold higher compared to controls

integument

impaired skin barrier function ( J:147182 )

• delay in skin barrier establishment

• at E17.5 the rate of water loss from the dorsal surface is about 3 fold higher compared to controls but no difference is detected at E18.5

• at E17.5 the rate of water loss from the ventral surface is slightly higher compared to controls and at E18.5 the rate of water loss from the dorsal surface is about 2 to 3 fold higher compared to controls

abnormal epidermal layer morphology ( J:147182 )

• expression analysis suggests that terminal differentiation is impaired

abnormal epidermis stratum corneum morphology ( J:147182 )

• modest reduction in the number of cornified cell layers at E17.5 and E18.5

• impaired surface distribution of neutral lipids