Phenotypes associated with this allele

• Allele Symbol: Tg(CD74*)1Ayr
• Allele Name: transgene insertion 1, Alexander Y Rudensky
• Allele ID: MGI:3839582
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Cd74^tm1Liz/Cd74^tm1Liz H2-DMa^tm1Luc/H2-DMa^tm1Luc Tg(CD74*)1Ayr/0	involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * DBA/2J	MGI:3839583

Genotype
MGI:3839583

cx1

• Allelic Composition: Cd74^tm1Liz/Cd74^tm1Liz; H2-DMa^tm1Luc/H2-DMa^tm1Luc; Tg(CD74*)1Ayr/0
• Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased CD4-positive, alpha-beta T cell number ( J:88717 )

• the number of CD4+ T cells is rescued to 60% of normal

abnormal antigen presentation via MHC class II ( J:88717 )

• Tg(CD74)AR194Ayr partially rescues the MHC class II peptide loading observed in Cd74^tm1Liz H2-DMa^tm1Luc homozygotes

• after incubation with Ealpha peptide, loading of MHC class II is greater than on similarly treated Cd74^tm1Liz H2-DMa^tm1Luc Tg(CD74)AR194Ayr splenocytes

• splenocytes elicit greater antigen presentations than in Cd74^tm1Liz H2-DMa^tm1Luc Tg(CD74)AR194Ayr splenocytes

• splenocytes elicit presentation of exogenous protein antigens derived from one but not two antigen

• splenocyte presentaton of IgM and beta-2 microglobulin epitpes is less efficient than in Cd74^tm1Liz Tg(CD74)AR194Ayr or Cd74^tm1Liz Tg(CD74*)AR194Ayr mice

• however, splenocytes can elicit presentation from two endogenous protein antigens (IgM and beta-2 microglobulin)

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:88717 )

• the number of CD4+ T cells is rescued to 60% of normal