Phenotypes associated with this allele

• Allele Symbol: Esr1^tm1Syeh
• Allele Name: targeted mutation 1, Shuyuan Yeh
• Allele ID: MGI:3839670
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Esr1^tm1Syeh/Esr1^tm1Syeh Tmem163^Tg(ACTB-cre)2Mrt/0	involves: 129X1/SvJ * FVB/N	MGI:3839856

Genotype
MGI:3839856

cn1

• Allelic Composition: Esr1^tm1Syeh/Esr1^tm1Syeh; Tmem163^{Tg(ACTB-cre)2Mrt}/0
• Genetic Background: involves: 129X1/SvJ * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased male germ cell number ( J:147000 )

♂

oligozoospermia ( J:147000 )

♂ • 10% of wild-type at 3 months of age

reproductive system

decreased male germ cell number ( J:147000 )

♂

oligozoospermia ( J:147000 )

♂ • 10% of wild-type at 3 months of age

abnormal female reproductive system morphology ( J:147191 )

♀

abnormal ovary morphology ( J:147191 )

♀ • ovaries have fewer interstitial compartments and greater number of atretic follicles compared to in wild-type mice

absent corpus luteum ( J:147191 )

♀

abnormal granulosa cell morphology ( J:147191 )

♀ • granulosa cell thickness in antral follicles is decreased compared to in wild-type mice

decreased primary ovarian follicle number ( J:147191 )

♀

decreased primordial ovarian follicle number ( J:147191 )

♀

increased atretic ovarian follicle number ( J:147191 )

♀

impaired ovarian folliculogenesis ( J:147191 )

♀ • folliculogenesis only progresses into the antral stage

ovary cyst ( J:147191 )

♀ • mice exhibit large dilated, hemorrhagic cysts unlike wild-type mice

abnormal myometrium morphology ( J:147191 )

♀ • the myometrium and lamina propria exhibit decreased numbers of stromal cells compared to in wild-type mice

uterus hypoplasia ( J:147191 )

♀ • mice exhibit decreased uterus diameter compared to in wild-type mice

♀ • however, uterus length is normal

vagina hypoplasia ( J:147191 )

♀

abnormal male reproductive system morphology ( J:147191 )

♂

abnormal prostate gland branching morphogenesis ( J:147000 )

♂ • the ventral and dorsal-lateral prostates contain fewer ductal tips, branches, and points compared to in wild-type prostates

♂ • however, prostate weight is normal

seminiferous tubule degeneration ( J:147000 )

♂ • the seminiferous tubules are atrophic and degenerating with disorganized epithelial unlike in wild-type mice

small testis ( J:147000 )

♂ • at 3 months of age

decreased testis weight ( J:147000 )

♂

abnormal reproductive system physiology ( J:147191 )

abnormal prostate gland physiology ( J:147000 )

♂ • stromal proliferation, specifically of fibroblasts, in the ventral prostate is less than in wild-type mice

♂ • while markers of fibroblast cells are decreased, expression of smooth muscle cell markers is increased in the prostate compared to in wild-type mice

♂ • however, epithelial proliferation is normal

female infertility ( J:147191 )

♀

male infertility ( J:147000 )

♂

growth/size/body

ovary cyst ( J:147191 )

♀ • mice exhibit large dilated, hemorrhagic cysts unlike wild-type mice

obese ( J:147191 )

• 12-week old female mice

adipose tissue

increased total body fat amount ( J:147191 )

• mice exhibit increased subcutaneous fat accumulation compared to in wild-type mice

homeostasis/metabolism

increased circulating testosterone level ( J:147000 )

• 2-fold higher in male mice than in wild-type mice

endocrine/exocrine glands

abnormal prostate gland branching morphogenesis ( J:147000 )

♂ • the ventral and dorsal-lateral prostates contain fewer ductal tips, branches, and points compared to in wild-type prostates

♂ • however, prostate weight is normal

abnormal ovary morphology ( J:147191 )

♀ • ovaries have fewer interstitial compartments and greater number of atretic follicles compared to in wild-type mice

absent corpus luteum ( J:147191 )

♀

abnormal granulosa cell morphology ( J:147191 )

♀ • granulosa cell thickness in antral follicles is decreased compared to in wild-type mice

decreased primary ovarian follicle number ( J:147191 )

♀

decreased primordial ovarian follicle number ( J:147191 )

♀

increased atretic ovarian follicle number ( J:147191 )

♀

impaired ovarian folliculogenesis ( J:147191 )

♀ • folliculogenesis only progresses into the antral stage

ovary cyst ( J:147191 )

♀ • mice exhibit large dilated, hemorrhagic cysts unlike wild-type mice

seminiferous tubule degeneration ( J:147000 )

♂ • the seminiferous tubules are atrophic and degenerating with disorganized epithelial unlike in wild-type mice

small testis ( J:147000 )

♂ • at 3 months of age

decreased testis weight ( J:147000 )

♂

abnormal prostate gland physiology ( J:147000 )

♂ • stromal proliferation, specifically of fibroblasts, in the ventral prostate is less than in wild-type mice

♂ • while markers of fibroblast cells are decreased, expression of smooth muscle cell markers is increased in the prostate compared to in wild-type mice

♂ • however, epithelial proliferation is normal