About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Esr1tm1Syeh
targeted mutation 1, Shuyuan Yeh
MGI:3839670
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Esr1tm1Syeh/Esr1tm1Syeh
Tmem163Tg(ACTB-cre)2Mrt/0 		involves: 129X1/SvJ * FVB/N MGI:3839856


Genotype
MGI:3839856
cn1
Allelic
Composition		 Esr1tm1Syeh/Esr1tm1Syeh
Tmem163Tg(ACTB-cre)2Mrt/0
Genetic
Background		 involves: 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Esr1tm1Syeh mutation (0 available); any Esr1 mutation (68 available)
Tmem163Tg(ACTB-cre)2Mrt mutation (3 available); any Tmem163 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
oligozoospermia ( J:147000 )
• 10% of wild-type at 3 months of age

reproductive system
oligozoospermia ( J:147000 )
• 10% of wild-type at 3 months of age
abnormal ovary morphology ( J:147191 )
• ovaries have fewer interstitial compartments and greater number of atretic follicles compared to in wild-type mice
abnormal granulosa cell morphology ( J:147191 )
• granulosa cell thickness in antral follicles is decreased compared to in wild-type mice
impaired ovarian folliculogenesis ( J:147191 )
• folliculogenesis only progresses into the antral stage
ovary cyst ( J:147191 )
• mice exhibit large dilated, hemorrhagic cysts unlike wild-type mice
abnormal myometrium morphology ( J:147191 )
• the myometrium and lamina propria exhibit decreased numbers of stromal cells compared to in wild-type mice
uterus hypoplasia ( J:147191 )
• mice exhibit decreased uterus diameter compared to in wild-type mice
• however, uterus length is normal
abnormal prostate gland branching morphogenesis ( J:147000 )
• the ventral and dorsal-lateral prostates contain fewer ductal tips, branches, and points compared to in wild-type prostates
• however, prostate weight is normal
seminiferous tubule degeneration ( J:147000 )
• the seminiferous tubules are atrophic and degenerating with disorganized epithelial unlike in wild-type mice
small testis ( J:147000 )
• at 3 months of age
abnormal prostate gland physiology ( J:147000 )
• stromal proliferation, specifically of fibroblasts, in the ventral prostate is less than in wild-type mice
• while markers of fibroblast cells are decreased, expression of smooth muscle cell markers is increased in the prostate compared to in wild-type mice
• however, epithelial proliferation is normal

growth/size/body
ovary cyst ( J:147191 )
• mice exhibit large dilated, hemorrhagic cysts unlike wild-type mice
obese ( J:147191 )
• 12-week old female mice

adipose tissue
increased total body fat amount ( J:147191 )
• mice exhibit increased subcutaneous fat accumulation compared to in wild-type mice

homeostasis/metabolism
increased circulating testosterone level ( J:147000 )
• 2-fold higher in male mice than in wild-type mice

endocrine/exocrine glands
abnormal prostate gland branching morphogenesis ( J:147000 )
• the ventral and dorsal-lateral prostates contain fewer ductal tips, branches, and points compared to in wild-type prostates
• however, prostate weight is normal
abnormal ovary morphology ( J:147191 )
• ovaries have fewer interstitial compartments and greater number of atretic follicles compared to in wild-type mice
abnormal granulosa cell morphology ( J:147191 )
• granulosa cell thickness in antral follicles is decreased compared to in wild-type mice
impaired ovarian folliculogenesis ( J:147191 )
• folliculogenesis only progresses into the antral stage
ovary cyst ( J:147191 )
• mice exhibit large dilated, hemorrhagic cysts unlike wild-type mice
seminiferous tubule degeneration ( J:147000 )
• the seminiferous tubules are atrophic and degenerating with disorganized epithelial unlike in wild-type mice
small testis ( J:147000 )
• at 3 months of age
abnormal prostate gland physiology ( J:147000 )
• stromal proliferation, specifically of fibroblasts, in the ventral prostate is less than in wild-type mice
• while markers of fibroblast cells are decreased, expression of smooth muscle cell markers is increased in the prostate compared to in wild-type mice
• however, epithelial proliferation is normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory