All Phenotypes Kmt2a<tm1.1Erns> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Kmt2a^tm1.1Erns
targeted mutation 1.1, Patricia Ernst
MGI:3839794

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Kmt2a^tm1.1Erns/Kmt2a^tm1.1Erns	involves: 129S2/SvPas * C57BL/6 * SJL	MGI:3839886
cn2	Cd19^tm1(cre)Cgn/Cd19⁺ Kmt2a^tm1.1Erns/Kmt2a^tm1.1Erns	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL	MGI:3839883
cn3	Kmt2a^tm1.1Erns/Kmt2a^tm1.1Erns Lyz2^tm1(cre)Ifo/Lyz2⁺	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL	MGI:3839885
cn4	Kmt2a^tm1.1Erns/Kmt2a^tm1.1Erns Tg(CAG-Bgeo/GFP)21Lbe/0	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ	MGI:3839881
cn5	Kmt2a^tm1.1Erns/Kmt2a^tm1.1Erns Tg(Mx1-cre)1Cgn/0	involves: 129S2/SvPas * C57BL/6 * CBA * SJL	MGI:3839882
cn6	Kmt2a^tm1.1Erns/Kmt2a^tm1.1Erns Tg(Lck-cre)1Cwi/0	involves: 129S2/SvPas * C57BL/6 * SJL	MGI:3839884
cn7	Kmt2a^tm1.1Erns/Kmt2a^tm1.1Erns Tg(GFAP-cre)25Mes/0	involves: 129S2/SvPas * FVB/N	MGI:3839880

Allelic Composition	Kmt2a^tm1.1Erns/Kmt2a^tm1.1Erns
Genetic Background	involves: 129S2/SvPas * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt2a^tm1.1Erns mutation (0 available); any Kmt2a mutation (135 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal definitive hematopoiesis ( J:147265 )

• retroviral cre-treated myelo-erythroid progenitor cells exhibit reduced proliferation and a 2.6-fold reduction in re-entry into the cell cycle following serum and cytokine starvation compared to wild-type cells

• however, the composition of cell populations produced is normal

decreased common myeloid progenitor cell number ( J:147265 )

• bone marrow cells treated with retroviral cre produce 2-fold fewer myeloid colony forming units compared to wild-type cells

decreased erythroid progenitor cell number ( J:147265 )

• bone marrow cells treated with retroviral cre produce 2-fold fewer erythroid colony forming units compared to wild-type cells

Allelic Composition	Cd19^tm1(cre)Cgn/Cd19⁺ Kmt2a^tm1.1Erns/Kmt2a^tm1.1Erns
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Kmt2a^tm1.1Erns mutation (0 available); any Kmt2a mutation (135 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:147265 )

N	• mice exhibit normally differentiating T, B, and myeloid cells

Allelic Composition	Kmt2a^tm1.1Erns/Kmt2a^tm1.1Erns Lyz2^tm1(cre)Ifo/Lyz2⁺
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt2a^tm1.1Erns mutation (0 available); any Kmt2a mutation (135 available)
Lyz2^tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:147265 )

N	• mice exhibit normally differentiating T, B, and myeloid cells

Allelic Composition	Kmt2a^tm1.1Erns/Kmt2a^tm1.1Erns Tg(CAG-Bgeo/GFP)21Lbe/0
Genetic Background	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt2a^tm1.1Erns mutation (0 available); any Kmt2a mutation (135 available)
Tg(CAG-Bgeo/GFP)21Lbe mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron differentiation ( J:147104 )

• subventricular neural stem cells treated in culture with adenoviral cre exhibit decreased differentiation compared to wild-type cells

• under differentiation condition, cultured subventricular zone cells treated with adenovirus cre produce 2-fold more oligodendrocytes and 50% more astrocytes than similarly treated wild-type cells

• however, proliferation and apoptosis rates are normal

decreased neuronal precursor cell number ( J:147104 )

• under differentiation condition, cultured subventricular zone cells treated with adenovirus cre produce 3-fold fewer Tuj1+ (marking neuron precursor cells) compared similarly treated wild-type cells

cellular

abnormal neuron differentiation ( J:147104 )

• subventricular neural stem cells treated in culture with adenoviral cre exhibit decreased differentiation compared to wild-type cells

• under differentiation condition, cultured subventricular zone cells treated with adenovirus cre produce 2-fold more oligodendrocytes and 50% more astrocytes than similarly treated wild-type cells

• however, proliferation and apoptosis rates are normal

Allelic Composition	Kmt2a^tm1.1Erns/Kmt2a^tm1.1Erns Tg(Mx1-cre)1Cgn/0
Genetic Background	involves: 129S2/SvPas * C57BL/6 * CBA * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt2a^tm1.1Erns mutation (0 available); any Kmt2a mutation (135 available)
Tg(Mx1-cre)1Cgn mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:147265 )

• mice die within days of pIpC treatment unlike similarly treated wild-type mice

• however, pIpC-treated mice injected with wild-type bone marrow survive

hematopoietic system

abnormal definitive hematopoiesis ( J:147265 )

• myelo-erythroid progenitor cells from pIpC-treated mice exhibit reduced proliferation and a 2.6-fold reduction in re-entry into the cell cycle following serum and cytokine starvation compared to wild-type cells

• however, the composition of cell populations produced is normal

decreased common myeloid progenitor cell number ( J:147265 )

• 11 days after pIpC, treatment common myeloid progenitors, granulocyte-progenitors, and megakaryocyte-erythrocyte progenitors are decreased 1.4- to 4-fold compared to in wild-type mice

• cultured bone marrow cells of pIpC-treated mice exhibit a 2- to 5-fold decrease in myeloid colonies compared to wild-type cells

decreased bone marrow cell number ( J:147265 )

• pIpC-treated mice exhibit bone marrow cytopenia unlike in wild-type mice

abnormal common lymphocyte progenitor cell morphology ( J:147265 )

• 11 days after pIpC treatment, lymphocyte progenitor cells are decreased 1.4- to 4-fold compared to in wild-type mice

• cultured bone marrow cells of pIpC-treated mice exhibit a 2- to 5-fold decrease in lymphoid colonies compared to wild-type cells

decreased erythroid progenitor cell number ( J:147265 )

• 11 days after pIpC, treatment common myeloid progenitors, granulocyte-progenitors, and megakaryocyte-erythrocyte progenitors are decreased 1.4- to 4-fold compared to in wild-type mice

• cultured bone marrow cells of pIpC-treated mice exhibit a 2- to 5-fold decrease in erythroid colonies compared to wild-type cells

abnormal hematopoietic stem cell morphology ( J:147265 )

• pIpC-treated mice exhibit a loss of hematopoietic stem cell (HSC) renewal followed by an increase in HSC proliferation and subsequent depletion of these cells unlike in wild-type mice

decreased hematopoietic stem cell number ( J:147265 )

• pIpC-treated mice exhibit a cell-intrinsic loss of hematopoietic stem cell-enriched KSL populations and loss of hematopoietic stem cell activity unlike similarly treated wild-type mice

Allelic Composition	Kmt2a^tm1.1Erns/Kmt2a^tm1.1Erns Tg(Lck-cre)1Cwi/0
Genetic Background	involves: 129S2/SvPas * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt2a^tm1.1Erns mutation (0 available); any Kmt2a mutation (135 available)
Tg(Lck-cre)1Cwi mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:147265 )

N	• mice exhibit normally differentiating T, B, and myeloid cells

Allelic Composition	Kmt2a^tm1.1Erns/Kmt2a^tm1.1Erns Tg(GFAP-cre)25Mes/0
Genetic Background	involves: 129S2/SvPas * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt2a^tm1.1Erns mutation (0 available); any Kmt2a mutation (135 available)
Tg(GFAP-cre)25Mes mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:147104 )

• mice die between P25 and P30

nervous system

abnormal neuron differentiation ( J:147104 )

• cultured subventricular cells produce fewer neuronal cells while remaining gliogenic unlike wild-type cells

• however, cultured subventricular cells exhibit normal proliferation and apoptosis

abnormal neuronal precursor cell migration ( J:147104 )

• neuroblast chain migration in mice and from subventricular zone explants is severely disorganized, and migration is reduced 40% compared to wild-type cells

abnormal brain development ( J:147104 )

• all regions of the brain that undergo postnatal neurogenesis including the cerebellar granule cell layer, hippocampal dentate gyrus, and olfactory bulb are reduced in size compared to in wild-type mice

• however, the ependymal layer and oligodendrocytes develop normally

abnormal dentate gyrus morphology ( J:147104 )

• reduced in size with reduced neurons

small olfactory bulb ( J:147104 )

• with reduced neurons

thin cerebellar granule layer ( J:147104 )

• with reduced neurons

abnormal postnatal subventricular zone morphology ( J:147104 )

• the expanded subventricular zone contains 3- to 4-fold fewer proliferating neuroblasts compared to in wild-type mice

• after P7, neuroblasts accumulate in the subventricular zone due to impaired migration unlike in wild-type mice

• the subventricular zone contains more cells positive for an astrocyte-specific marker than in wild-type mice

abnormal astrocyte morphology ( J:147104 )

• the subventricular zone and other brain regions contains more cells positive for an astrocyte-specific marker than in wild-type mice

decreased neuronal precursor cell number ( J:147104 )

• the subventricular zone contains 3- to 4-fold fewer proliferating neuroblasts compared to in wild-type mice

• under differentiation condition, cultured subventricular zone cells produce more than 20-fold fewer Tuj1+ (marking neuron precursor cells) compared similarly treated wild-type cells

behavior/neurological

ataxia ( J:147104 )

growth/size/body

postnatal growth retardation ( J:147104 )

• progressive

cellular

abnormal neuron differentiation ( J:147104 )

• cultured subventricular cells produce fewer neuronal cells while remaining gliogenic unlike wild-type cells

• however, cultured subventricular cells exhibit normal proliferation and apoptosis

abnormal neuronal precursor cell migration ( J:147104 )

• neuroblast chain migration in mice and from subventricular zone explants is severely disorganized, and migration is reduced 40% compared to wild-type cells

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