All Phenotypes Gt(ROSA)26Sor<tm2(sb11)Njen> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gt(ROSA)26Sor^{tm2(sb11)Njen}
targeted mutation 2, Nancy A Jenkins
MGI:3839796

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Aicda^tm1(cre)Mnz/Aicda⁺ Gt(ROSA)26Sor^{tm2(sb11)Njen}/Gt(ROSA)26Sor⁺ TgTn(sb-T2/Onc2)6070Njen/0	involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J	MGI:4367198
cn2	Gt(ROSA)26Sor^{tm2(sb11)Njen}/Gt(ROSA)26Sor⁺ TgTn(sb-T2/Onc2)6070Njen/0	involves: 129 * C57BL/6 * C57BL/6J	MGI:4367197
cn3	Gt(ROSA)26Sor^{tm2(sb11)Njen}/Gt(ROSA)26Sor⁺ Trp53^tm3Tyj/Trp53⁺ Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ TgTn(sb-T2/Onc)68Dla/0	involves: 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N	MGI:3839859
cn4	Gt(ROSA)26Sor^{tm2(sb11)Njen}/Gt(ROSA)26Sor⁺ Tg(Vil1-cre)20Syr/0 TgTn(sb-T2/Onc)68Dla/0	involves: C57BL/6 * DBA/2 * FVB/N	MGI:3839797
cn5	Gt(ROSA)26Sor^{tm2(sb11)Njen}/Gt(ROSA)26Sor⁺ Tg(Vil1-cre)20Syr/0 TgTn(sb-T2/Onc)76Dla/0	involves: C57BL/6 * DBA/2 * FVB/N	MGI:3839798
cn6	Gt(ROSA)26Sor^{tm2(sb11)Njen}/Gt(ROSA)26Sor⁺ Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ TgTn(sb-T2/Onc)68Dla/0	involves: C57BL/6 * DBA/2 * FVB/N	MGI:3839857

Allelic Composition	Aicda^tm1(cre)Mnz/Aicda⁺ Gt(ROSA)26Sor^{tm2(sb11)Njen}/Gt(ROSA)26Sor⁺ TgTn(sb-T2/Onc2)6070Njen/0
Genetic Background	involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicda^tm1(cre)Mnz mutation (1 available); any Aicda mutation (57 available)
Gt(ROSA)26Sor^{tm2(sb11)Njen} mutation (7 available); any Gt(ROSA)26Sor mutation (993 available)
TgTn(sb-T2/Onc2)6070Njen mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:153656 )

• compared with Gt(ROSA)26Sor^{tm2(sb11)Njen} TgTn(sb-T2/Onc2)6070Njen mice

neoplasm

increased tumor incidence ( J:153656 )

• greater than 90% of moribund mice develop tumors with an average latency of 46 weeks

increased skin squamous cell carcinoma incidence ( J:153656 )

• in one mouse

increased medulloblastoma incidence ( J:153656 )

• in one mouse

increased hemolymphoid system tumor incidence ( J:153656 )

• mice develop hematopoietic tumors including B cell, T cell, and myeloid tumors unlike Gt(ROSA)26Sor^{tm2(sb11)Njen} TgTn(sb-T2/Onc2)6070Njen mice that do not develop tumors

increased T cell derived lymphoma incidence ( J:153656 )

• 3 T cell lymphomas develop

increased leukemia incidence ( J:153656 )

• 2 myeloid leukemia tumors develop

increased B cell derived lymphoma incidence ( J:153656 )

• mice develop B cell lymphomas including diffuse large cell lymphomas and follicular lymphomas

• one mouse developed pre-B lymphoma

increased follicular lymphoma incidence ( J:153656 )

integument

increased skin squamous cell carcinoma incidence ( J:153656 )

• in one mouse

nervous system

increased medulloblastoma incidence ( J:153656 )

• in one mouse

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:153656 )

• 3 T cell lymphomas develop

immune system

increased T cell derived lymphoma incidence ( J:153656 )

• 3 T cell lymphomas develop

hematopoietic system

increased T cell derived lymphoma incidence ( J:153656 )

• 3 T cell lymphomas develop

Allelic Composition	Gt(ROSA)26Sor^{tm2(sb11)Njen}/Gt(ROSA)26Sor⁺ TgTn(sb-T2/Onc2)6070Njen/0
Genetic Background	involves: 129 * C57BL/6 * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to infection ( J:153656 )

• 2 mice develop urinary tract infections

liver/biliary system

liver cirrhosis ( J:153656 )

• in one mouse

muscle

muscle degeneration ( J:153656 )

• one mouse exhibited myocyte degeneration

integument

abnormal skin condition ( J:153656 )

• one mouse exhibited skin irritation

Allelic Composition	Gt(ROSA)26Sor^{tm2(sb11)Njen}/Gt(ROSA)26Sor⁺ Trp53^tm3Tyj/Trp53⁺ Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ TgTn(sb-T2/Onc)68Dla/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm2(sb11)Njen} mutation (7 available); any Gt(ROSA)26Sor mutation (993 available)
Speer6-ps1^{Tg(Alb-cre)21Mgn} mutation (6 available); any Speer6-ps1 mutation (4 available)
TgTn(sb-T2/Onc)68Dla mutation (1 available)
Trp53^tm3Tyj mutation (3 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased hepatocellular carcinoma incidence ( J:147264 )

• seen in older males

increased liver adenoma incidence ( J:147264 )

• tumor formation is more prevalent and starts earlier in males compared to females

liver/biliary system

abnormal liver morphology ( J:147264 )

• preneoplastic nodules are first detected at about 160 days of age in males

• liver nodules in quadruple transgenic mice are larger and more numerous compared to triple transgenic mice that are wild-type at the Trp53 locus

increased hepatocellular carcinoma incidence ( J:147264 )

• seen in older males

increased liver adenoma incidence ( J:147264 )

• tumor formation is more prevalent and starts earlier in males compared to females

Allelic Composition	Gt(ROSA)26Sor^{tm2(sb11)Njen}/Gt(ROSA)26Sor⁺ Tg(Vil1-cre)20Syr/0 TgTn(sb-T2/Onc)68Dla/0
Genetic Background	involves: C57BL/6 * DBA/2 * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:146887 )

neoplasm

increased gastrointestinal tumor incidence ( J:146887 )

• increased incidence of intraepithelial neoplasias in the small and large intestines

increased small intestine adenocarcinoma incidence ( J:146887 )

increased intestinal adenoma incidence ( J:146887 )

• adenomas are seen in the small and large intestines

digestive/alimentary system

increased gastrointestinal tumor incidence ( J:146887 )

• increased incidence of intraepithelial neoplasias in the small and large intestines

increased small intestine adenocarcinoma incidence ( J:146887 )

increased intestinal adenoma incidence ( J:146887 )

• adenomas are seen in the small and large intestines

Allelic Composition	Gt(ROSA)26Sor^{tm2(sb11)Njen}/Gt(ROSA)26Sor⁺ Tg(Vil1-cre)20Syr/0 TgTn(sb-T2/Onc)76Dla/0
Genetic Background	involves: C57BL/6 * DBA/2 * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:146887 )

neoplasm

increased gastrointestinal tumor incidence ( J:146887 )

• increased incidence of intraepithelial neoplasias in the small and large intestines

increased small intestine adenocarcinoma incidence ( J:146887 )

increased intestinal adenoma incidence ( J:146887 )

• adenomas are seen in the small and large intestines

digestive/alimentary system

increased gastrointestinal tumor incidence ( J:146887 )

• increased incidence of intraepithelial neoplasias in the small and large intestines

increased small intestine adenocarcinoma incidence ( J:146887 )

increased intestinal adenoma incidence ( J:146887 )

• adenomas are seen in the small and large intestines

Allelic Composition	Gt(ROSA)26Sor^{tm2(sb11)Njen}/Gt(ROSA)26Sor⁺ Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ TgTn(sb-T2/Onc)68Dla/0
Genetic Background	involves: C57BL/6 * DBA/2 * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased hepatocellular carcinoma incidence ( J:147264 )

• seen in older males

increased liver adenoma incidence ( J:147264 )

• tumor formation is more prevalent and starts earlier in males compared to females

liver/biliary system

abnormal liver morphology ( J:147264 )

• preneoplastic nodules are first detected at about 160 days of age in males

increased hepatocellular carcinoma incidence ( J:147264 )

• seen in older males

increased liver adenoma incidence ( J:147264 )

• tumor formation is more prevalent and starts earlier in males compared to females

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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