Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sim1tm1.1(cre)Gld mutation
(0 available);
any
Sim1 mutation
(52 available)
Tg(CAG-Bgeo,-AlstR,-EGFP)192Gld mutation
(0 available)
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nervous system
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• marked decrease in the rhythmicity of spinal cord locomotor like outputs and increase in the variance of flexor related bursts between the left and right halves in the presence of allatostatin
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behavior/neurological
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• after application of allatostatin to the L2 - L4 segments 5 of 8 mice showed profound changes in their gate with changes in the timing and duration of both the stance and swing phases of the gait
• however, in the absence of treatment no gait abnormalities were seen
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(GFP/tetX)Gld mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(993 available)
Sim1tm1.1(cre)Gld mutation
(0 available);
any
Sim1 mutation
(52 available)
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nervous system
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• electroneurogram recordings from ventral roots indicates a suppression of synaptic transmission disrupting locomotor rhythm
• outputs from spinal cords show increased variability in the duration of individual motor bursts and in the length of the step cycle period which may be coupled with asymmetry in the duration of flexor bursts between the right and left sides of the spinal cord
• spinal cords show impaired production of locomotor like oscillations following induction with NMDA and 5-hydroxytryptamine or after electrical stimulation of sensory afferents
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Analysis Tools