Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm2(GFP/tetX)Gld}
• Allele Name: targeted mutation 2, Martyn Goulding
• Allele ID: MGI:3839913
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm2(GFP/tetX)Gld/Gt(ROSA)26Sor^+ Tg(Nes-cre)1Kln/0	involves: C57BL/6 * SJL	MGI:3839916
cn2	Gt(ROSA)26Sor^tm2(GFP/tetX)Gld/Gt(ROSA)26Sor^+ Sim1^tm1.1(cre)Gld/Sim1^+	involves: C57BL/6 * SJL	MGI:3839917

Genotype
MGI:3839916

cn1

• Allelic Composition: Gt(ROSA)26Sor^{tm2(GFP/tetX)Gld}/Gt(ROSA)26Sor⁺; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal CNS synaptic transmission ( J:147245 )

• block of synaptic transmission between spinal neurons that is necessary for fictive locomotion

Genotype
MGI:3839917

cn2

• Allelic Composition: Gt(ROSA)26Sor^{tm2(GFP/tetX)Gld}/Gt(ROSA)26Sor⁺; Sim1^{tm1.1(cre)Gld}/Sim1⁺
• Genetic Background: involves: C57BL/6 * SJL

nervous system

abnormal CNS synaptic transmission ( J:147245 )

• electroneurogram recordings from ventral roots indicates a suppression of synaptic transmission disrupting locomotor rhythm

• outputs from spinal cords show increased variability in the duration of individual motor bursts and in the length of the step cycle period which may be coupled with asymmetry in the duration of flexor bursts between the right and left sides of the spinal cord

• spinal cords show impaired production of locomotor like oscillations following induction with NMDA and 5-hydroxytryptamine or after electrical stimulation of sensory afferents