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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(CAG-Bgeo,-AlstR,-EGFP)192Gld
transgene insertion 192, Martyn Goulding
MGI:3839915
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		En1tm2(cre)Gld/En1+
Tg(CAG-Bgeo,-AlstR,-EGFP)192Gld/0 		involves: 129S1/Sv MGI:3839922
cn2
 		Sim1tm1.1(cre)Gld/Sim1+
Tg(CAG-Bgeo,-AlstR,-EGFP)192Gld/0 		involves: 129S1/Sv * C57BL/6 * SJL MGI:3839918


Genotype
MGI:3839922
cn1
Allelic
Composition		 En1tm2(cre)Gld/En1+
Tg(CAG-Bgeo,-AlstR,-EGFP)192Gld/0
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1tm2(cre)Gld mutation (0 available); any En1 mutation (34 available)
Tg(CAG-Bgeo,-AlstR,-EGFP)192Gld mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal CNS synaptic transmission ( J:106437 )
• decrease in V1 neuron excitability in response to current steps and ramps after allatostatin treatment
• application of allatostatin to spinal cords increases the length of the step cycle period




Genotype
MGI:3839918
cn2
Allelic
Composition		 Sim1tm1.1(cre)Gld/Sim1+
Tg(CAG-Bgeo,-AlstR,-EGFP)192Gld/0
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sim1tm1.1(cre)Gld mutation (0 available); any Sim1 mutation (52 available)
Tg(CAG-Bgeo,-AlstR,-EGFP)192Gld mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal CNS synaptic transmission ( J:147245 )
• marked decrease in the rhythmicity of spinal cord locomotor like outputs and increase in the variance of flexor related bursts between the left and right halves in the presence of allatostatin

behavior/neurological
abnormal gait ( J:147245 )
• after application of allatostatin to the L2 - L4 segments 5 of 8 mice showed profound changes in their gate with changes in the timing and duration of both the stance and swing phases of the gait
• however, in the absence of treatment no gait abnormalities were seen




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory