Analysis Tools
hematopoietic system
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• during the chronic phase of antigen exposure are decreased compared to in wild-type mice
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• during the early phase of antigen exposure mast cell numbers are increased compared to in wild-type mice
• however, treatment with P-selectin antibodies reduces the number of mast cells at the sight of inflammation
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immune system
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• during the chronic phase of antigen exposure are decreased compared to in wild-type mice
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• during the early phase of antigen exposure mast cell numbers are increased compared to in wild-type mice
• however, treatment with P-selectin antibodies reduces the number of mast cells at the sight of inflammation
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• oxazolone-treated ears exhibit a more rapid onset of ear swelling and increased ear thickness between days 2 and 6 compared to similarly treated wild-type mice
• acute inflammatory response to oxazolone exposure is exacerbated compared to in similarly treated wild-type mice
• chronic inflammation in response to oxazolone exposure is inhibited compared to in similarly treated wild-type mice
• 24 and 48 hours after elicitation, antigen-exposed ears of mice treated with P-selectin antibodies at 0-hour exhibit a 70% to 80% inhibition in swelling compared to in wild-type mice
• 48 hours after elicitation, antigen-exposed ears of mice treated with P-selectin antibodies at 24-hour exhibit a modest inhibition in swelling compared to in wild-type mice
• however, oxazolone-treated ears have the same thickness as similarly treated wild-type ears at day 8 or 10 of treatment
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