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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Selltm4Hyn
targeted mutation 4, Richard Hynes
MGI:3839979
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Selltm4Hyn/Selltm4Hyn
Selptm1Hyn/Selptm1Hyn 		involves: 129S2/SvPas * C57BL/6 MGI:3840203


Genotype
MGI:3840203
cx1
Allelic
Composition		 Selltm4Hyn/Selltm4Hyn
Selptm1Hyn/Selptm1Hyn
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Selltm4Hyn mutation (1 available); any Sell mutation (42 available)
Selptm1Hyn mutation (12 available); any Selp mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired leukocyte tethering or rolling ( J:57973 )
• there is also slight decrease in the number of adhering leukocytes within these mesenteric venules
• a population of leukocytes that are "fast rollers" is evident in these mice that are not observed in wild-type mice
increased eosinophil cell number ( J:57973 )
• eosinophil numbers are about two-thirds higher in the blood
impaired neutrophil recruitment ( J:57973 )
• neutrophil influx in thioglycollate-induced peritonitis is inhibited at 2, 4, and 8 hours after injection compared to wild-type mice
• lower numbers of neutrophils are observedat 2 hours than those elicited from mice that are null homozygotes for just one gene

hematopoietic system
impaired leukocyte tethering or rolling ( J:57973 )
• there is also slight decrease in the number of adhering leukocytes within these mesenteric venules
• a population of leukocytes that are "fast rollers" is evident in these mice that are not observed in wild-type mice
increased eosinophil cell number ( J:57973 )
• eosinophil numbers are about two-thirds higher in the blood
impaired neutrophil recruitment ( J:57973 )
• neutrophil influx in thioglycollate-induced peritonitis is inhibited at 2, 4, and 8 hours after injection compared to wild-type mice
• lower numbers of neutrophils are observedat 2 hours than those elicited from mice that are null homozygotes for just one gene

cellular
impaired leukocyte tethering or rolling ( J:57973 )
• there is also slight decrease in the number of adhering leukocytes within these mesenteric venules
• a population of leukocytes that are "fast rollers" is evident in these mice that are not observed in wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory