All Phenotypes Brd2<Gt(RRE050)Byg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Brd2^{Gt(RRE050)Byg}
gene trap RRE050, BayGenomics
MGI:3840071

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Brd2^{Gt(RRE050)Byg}/Brd2^{Gt(RRE050)Byg}	involves: 129P2/OlaHsd * C57BL/6J	MGI:3840072
ht2	Brd2^{Gt(RRE050)Byg}/Brd2⁺	involves: 129P2/OlaHsd * C57BL/6J	MGI:3840073

Allelic Composition	Brd2^{Gt(RRE050)Byg}/Brd2^{Gt(RRE050)Byg}
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brd2^{Gt(RRE050)Byg} mutation (0 available); any Brd2 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:147040 )

• embryos die between E10.5 and E12.5

• tetraploid rescue does not permit survival beyond E12.5

embryo

increased embryonic tissue cell apoptosis ( J:147040 )

• in whole embryos at E9.5

decreased embryo size ( J:147040 )

• at E8.5 and E9.5

abnormal neural tube closure ( J:147040 )

• defects in neural tube closure at E9.5

cellular

abnormal cell cycle ( J:147040 )

• delay in the G1 phase of the cell cycle

abnormal cell death ( J:147040 )

• most cells derived from homozygous embryos die after the first plating

increased embryonic tissue cell apoptosis ( J:147040 )

• in whole embryos at E9.5

decreased cell proliferation ( J:147040 )

• MEFs grow more slowly and stop growing at lower cell densities compared to controls

nervous system