Phenotypes associated with this allele

• Allele Symbol: Nup155^{Gt(RRD107)Byg}
• Allele Name: gene trap RRD107, BayGenomics
• Allele ID: MGI:3840086
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nup155^Gt(RRD107)Byg/Nup155^Gt(RRD107)Byg	involves: 129P2/OlaHsd	MGI:3840094
ht2	Nup155^Gt(RRD107)Byg/Nup155^+	involves: 129P2/OlaHsd	MGI:3840095

Genotype
MGI:3840094

hm1

• Allelic Composition: Nup155^{Gt(RRD107)Byg}/Nup155^{Gt(RRD107)Byg}
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:147210 )

• mice die prior to E8.5

Genotype
MGI:3840095

ht2

• Allelic Composition: Nup155^{Gt(RRD107)Byg}/Nup155⁺
• Genetic Background: involves: 129P2/OlaHsd

cardiovascular system

cardiovascular system phenotype ( J:147210 )

N • no overt structural abnormalities in heart and skeletal muscle are seen

N • no overt differences in the morphology of cardiomyocytes and the atrial tissue architecture are seen

atrial fibrillation ( J:147210 )

• mice develop atrial fibrillation unlike wild-type mice

abnormal impulse conducting system conduction ( J:147210 )

absent P wave ( J:147210 )

• mice lack discrete P waves

abnormal RR interval ( J:147210 )

• mice exhibit irregular R-R intervals unlike in wild-type mice

nervous system

abnormal action potential ( J:147210 )

• atrial myocytes exhibit shortened action potential duration compared to in wild-type mice