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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pik3r5tm1Lste
targeted mutation 1, Len Stephens
MGI:3840090
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pik3r5tm1Lste/Pik3r5tm1Lste involves: 129P2/OlaHsd MGI:5903755
hm2
 		Pik3r5tm1Lste/Pik3r5tm1Lste involves: 129P2/OlaHsd * C57BL/6 MGI:3840103


Genotype
MGI:5903755
hm1
Allelic
Composition		 Pik3r5tm1Lste/Pik3r5tm1Lste
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3r5tm1Lste mutation (0 available); any Pik3r5 mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired neutrophil chemotaxis ( J:238900 )
• after thioglycollate injection

cellular
impaired neutrophil chemotaxis ( J:238900 )
• after thioglycollate injection

hematopoietic system
impaired neutrophil chemotaxis ( J:238900 )
• after thioglycollate injection




Genotype
MGI:3840103
hm2
Allelic
Composition		 Pik3r5tm1Lste/Pik3r5tm1Lste
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3r5tm1Lste mutation (0 available); any Pik3r5 mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired neutrophil chemotaxis ( J:147259 )
• reduced chemotactic and chemokinetic response to fMLP, C5a, or MIP2
impaired neutrophil recruitment ( J:147259 )
• reduced recruitment to the peritoneum in thioglycollate induced peritonitis

cellular
impaired neutrophil chemotaxis ( J:147259 )
• reduced chemotactic and chemokinetic response to fMLP, C5a, or MIP2

hematopoietic system
impaired neutrophil chemotaxis ( J:147259 )
• reduced chemotactic and chemokinetic response to fMLP, C5a, or MIP2
impaired neutrophil recruitment ( J:147259 )
• reduced recruitment to the peritoneum in thioglycollate induced peritonitis




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory