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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Myod1tm2.1(icre)Glh
targeted mutation 2.1, David J Goldhamer
MGI:3840216
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Abl1tm1Gcos/Abl1+
Myf5tm2Tajb/Myf5tm2Tajb
Myf6tm1Tajb/Myf6tm1Tajb
Myod1tm2.1(icre)Glh/Myod1+ 		involves: 129S * 129X1/SvJ * C57BL/6J MGI:4939891
cn2
 		Acvr1tm1Glh/Acvr1+
Myod1tm2.1(icre)Glh/Myod1+ 		involves: 129S6/SvEvTac * C57BL/6J * FVB/N MGI:7278769


Genotype
MGI:4939891
cn1
Allelic
Composition		 Abl1tm1Gcos/Abl1+
Myf5tm2Tajb/Myf5tm2Tajb
Myf6tm1Tajb/Myf6tm1Tajb
Myod1tm2.1(icre)Glh/Myod1+
Genetic
Background		 involves: 129S * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abl1tm1Gcos mutation (0 available); any Abl1 mutation (93 available)
Myf5tm2Tajb mutation (0 available); any Myf5 mutation (17 available)
Myf6tm1Tajb mutation (0 available); any Myf6 mutation (19 available)
Myod1tm2.1(icre)Glh mutation (1 available); any Myod1 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
abnormal myogenesis ( J:168843 )
• skeletal myogenesis is not suppressed by genotoxins unlike in wild-type mice

homeostasis/metabolism
decreased physiological sensitivity to xenobiotic ( J:168843 )
• skeletal myogenesis is not suppressed by genotoxins unlike in wild-type mice




Genotype
MGI:7278769
cn2
Allelic
Composition		 Acvr1tm1Glh/Acvr1+
Myod1tm2.1(icre)Glh/Myod1+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acvr1tm1Glh mutation (0 available); any Acvr1 mutation (44 available)
Myod1tm2.1(icre)Glh mutation (1 available); any Myod1 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
skeleton phenotype ( J:257905 )
N
• pinch or cardiotoxin-mediated injury of the gastrocnemius or tibialis anterior hindlimb muscles of adults does not cause heterotopic ossification




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory