mortality/aging
• severely affect mice do not survive, no time of lethality provided
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cardiovascular system
• seen at E13.5 in severely affected embryos
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• increased size of the atrioventricular valve primordia
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• seen at E13.5 in severely affected embryos
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• atrial septal defects may be seen in severely affected embryos at E13.5
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• ventricular septal defects may be seen in severely affected embryos at E13.5
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growth/size/body
• seen in surviving mice
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• seen in surviving mice
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craniofacial
vision/eye
• increased inner canthal distance
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hematopoietic system
• increase in the number of CFU-GM in the absence of cytokines compared to wild-type controls
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skeleton
muscle
• seen at E13.5 in severely affected embryos
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