All Phenotypes Ptpn11<tm7Bgn> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptpn11^tm7Bgn/Ptpn11^tm7Bgn	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6	MGI:3840257
ht2	Ptpn11^tm7Bgn/Ptpn11⁺	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6	MGI:3840258

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:147154 )

• severely affect mice do not survive, no time of lethality provided

cardiovascular system

thin myocardium ( J:147154 )

• seen at E13.5 in severely affected embryos

increased atrioventricular cushion size ( J:147154 )

• increased size of the atrioventricular valve primordia

double outlet right ventricle ( J:147154 )

• seen at E13.5 in severely affected embryos

atrial septal defect ( J:147154 )

• atrial septal defects may be seen in severely affected embryos at E13.5

ventricular septal defect ( J:147154 )

• ventricular septal defects may be seen in severely affected embryos at E13.5

growth/size/body

decreased body weight ( J:147154 )

• seen in surviving mice

decreased body length ( J:147154 )

• seen in surviving mice

craniofacial

decreased cranium height ( J:147154 )

vision/eye

increased inner canthal distance ( J:147154 )

• increased inner canthal distance

hematopoietic system

abnormal common myeloid progenitor cell morphology ( J:147154 )

• increase in the number of CFU-GM in the absence of cytokines compared to wild-type controls

skeleton

decreased cranium height ( J:147154 )

muscle

thin myocardium ( J:147154 )

• seen at E13.5 in severely affected embryos

Allelic Composition	Ptpn11^tm7Bgn/Ptpn11⁺
Genetic Background	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptpn11^tm7Bgn mutation (1 available); any Ptpn11 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:147154 )

decreased body length ( J:147154 )

craniofacial

decreased cranium height ( J:147154 )

hematopoietic system

abnormal common myeloid progenitor cell morphology ( J:147154 )

• increase in the number of CFU-GM in the absence of cytokines compared to wild-type controls

skeleton

decreased cranium height ( J:147154 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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