Phenotypes associated with this allele

• Allele Symbol: Cyp1a^tm1.1Bra
• Allele Name: targeted mutation 1.1, Christopher A Bradfield
• Allele ID: MGI:3840319
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cyp1a^tm1.1Bra/Cyp1a^tm1.1Bra	B6.129-Cyp1a^tm1.1Bra	MGI:3840321

Genotype
MGI:3840321

hm1

• Allelic Composition: Cyp1a^tm1.1Bra/Cyp1a^tm1.1Bra
• Genetic Background: B6.129-Cyp1a^tm1.1Bra

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Increased liver inflammation and decreased hydropic degeneration in MGI:3840320/MGI:3840320 mice in response to dioxin-induced toxicity

homeostasis/metabolism

abnormal physiological response to xenobiotic ( J:147150 )

• following dioxin exposure no increase in expression of Cyp1a1 RNA and a much lower degree of increase in expression of Cyp1a2 are detected

• after dioxin treatment (64 ug/kg) mice show increased levels of liver inflammation and serum ALT but lower levels of hydropic degeneration

cardiovascular system

cardiovascular system phenotype ( J:147150 )

N • unlike in Ahr null mice, the ductus venosus closes during development