Phenotypes associated with this allele

• Allele Symbol: Grm5^tm1.2Jixu
• Allele Name: targeted mutation 1.2, Jian Xu
• Allele ID: MGI:3840382
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grm5^tm1.2Jixu/Grm5^tm1.2Jixu	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6	MGI:3840440

Genotype
MGI:3840440

hm1

• Allelic Composition: Grm5^tm1.2Jixu/Grm5^tm1.2Jixu
• Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal contextual conditioning behavior ( J:147275 )

• decrease in context related freezing 24 hours after training compared to controls

• however, freeze response to the auditory signal is similar to controls

abnormal cued conditioning behavior ( J:147275 )

• increase in time spent frozen after repeated trials of paired shock and tone is less than in controls

• however, pain response is similar to controls

abnormal latent inhibition of conditioning behavior ( J:147275 )

• fear extinction following multiple exposures to a context or an auditory signal is absent

abnormal inhibitory learning ( J:147275 )

• impairment in performance in a Morris water maze when the hidden platform is moved to a new location with mice spending more time than controls searching the former platform location in probe tests

• however, no impairment is seen in the ability of mice to learn the initial location of the platform