Phenotypes associated with this allele

• Allele Symbol: Lypd1^tm1.1Tmj
• Allele Name: targeted mutation 1.1, Thomas M Jessell
• Allele ID: MGI:3840549
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lypd1^tm1.1Tmj/Lypd1^tm1.1Tmj	involves: C57BL/6 * FVB/N	MGI:3840553

Genotype
MGI:3840553

hm1

• Allelic Composition: Lypd1^tm1.1Tmj/Lypd1^tm1.1Tmj
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:146775 )

N • mice exhibit normal open field locomotion, hot plate response, and finding of buried food

abnormal passive avoidance behavior ( J:146775 )

• on day 1 of a passive avoidance task, mice spend more time before they entered the mysterious dark compartment compared to wild-type mice

• however, mice display normal avoidance learning on days 2 and 3

abnormal cued conditioning behavior ( J:146775 )

• in a cued conditioning assay, mice exhibit increased freezing compared to wild-type mice

increased anxiety-related response ( J:146775 )

• in a light-dark exploration test, mice spend less time in the light and made fewer transitions to the light compartment compared to wild-type mice

• mice spend less time interacting with a novel mouse compared to wild-type mice

• in an elevated plus maze, mice exhibit fewer transition to and spend less time in the open arms compared to wild-type mice

increased fear-related response ( J:146775 )

• in a conditioned fear assays, mice exhibit increased freezing compared to wild-type mice

nervous system

abnormal excitatory postsynaptic currents ( J:146775 )

• following treatment with nicotine, mice exhibit a greater increase in spontaneous excitatory postsynaptic current compared to similarly treated wild-type mice