About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lats1tm1Noj
targeted mutation 1, Hiroshi Nojima
MGI:3840659
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Lats1tm1Noj/Lats1tm1Noj involves: 129S2/SvPas * C57BL/6 MGI:4412186
cn2
 		Lats1tm1Noj/Lats1tm1Noj
Lats2tm1.1Dupa/Lats2tm1.1Dupa 		involves: 129P2/OlaHsd * 129S2/SvPas MGI:5660302
cn3
 		Lats1tm1Noj/Lats1tm1Noj
Lats2tm1.1Dupa/Lats2tm1.1Dupa
Wwtr1tm1.2Eno/Wwtr1tm1.2Eno
Yap1tm1.1Dupa/Yap1tm1.1Dupa 		involves: 129P2/OlaHsd * 129S/SvEv * 129S2/SvPas MGI:5660349


Genotype
MGI:4412186
hm1
Allelic
Composition		 Lats1tm1Noj/Lats1tm1Noj
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lats1tm1Noj mutation (1 available); any Lats1 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:200232 )
• fewer than expected mice are present at birth

cellular
abnormal centrosome morphology ( J:200232 )
• centrosomal overduplication in mouse embryonic fibroblasts that gradually diminishes over successive passages
abnormal cell physiology ( J:200232 )
• mouse embryonic fibroblasts escape contact inhibition 5 days after the confluent stage and pile up after 12 days unlike wild-type mice
abnormal mitosis ( J:200232 )
• mouse embryonic fibroblasts exhibit chromosomal misalignment, multipolar spindle formation, chromosomal bridging and cytokinesis failure unlike wild-type cells
abnormal mitotic spindle morphology ( J:200232 )
• multipolar spindle formation in mouse embryonic fibroblasts
increased fibroblast proliferation ( J:200232 )
• mouse embryonic fibroblasts grown on nanoculture plates or 3D collagen gels exhibit accelerated growth and spheroid formation compared with wild-type cells

growth/size/body
decreased body weight ( J:200232 )
• until 4 weeks after birth
postnatal growth retardation ( J:200232 )

neoplasm
neoplasm ( J:200232 )
N
• mice do not develop tumors unlike Lats1tm1Tx homozygotes
abnormal tumor morphology ( J:200232 )
• mouse embryonic fibroblasts injected into nude mice produce tumors that grow slower than ordinary epithelial cancer cells unlike wild-type cells




Genotype
MGI:5660302
cn2
Allelic
Composition		 Lats1tm1Noj/Lats1tm1Noj
Lats2tm1.1Dupa/Lats2tm1.1Dupa
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lats1tm1Noj mutation (1 available); any Lats1 mutation (52 available)
Lats2tm1.1Dupa mutation (1 available); any Lats2 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal bile duct epithelium morphology ( J:223215 )
• extensive proliferation of cryokeratin-positive biliary epithelial cells observed in liver following adenovirus expressing Cre recombinase (Ad-Cre) injection

liver/biliary system
abnormal bile duct epithelium morphology ( J:223215 )
• extensive proliferation of cryokeratin-positive biliary epithelial cells observed in liver following adenovirus expressing Cre recombinase (Ad-Cre) injection
enlarged liver ( J:223215 )
• mice develop hepatomegaly 8 weeks after Ad-Cre injection
increased liver weight ( J:223215 )
• liver size reaches 30% of body weight 8 weeks after Ad-Cre injection

growth/size/body
enlarged liver ( J:223215 )
• mice develop hepatomegaly 8 weeks after Ad-Cre injection
increased liver weight ( J:223215 )
• liver size reaches 30% of body weight 8 weeks after Ad-Cre injection




Genotype
MGI:5660349
cn3
Allelic
Composition		 Lats1tm1Noj/Lats1tm1Noj
Lats2tm1.1Dupa/Lats2tm1.1Dupa
Wwtr1tm1.2Eno/Wwtr1tm1.2Eno
Yap1tm1.1Dupa/Yap1tm1.1Dupa
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv * 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lats1tm1Noj mutation (1 available); any Lats1 mutation (52 available)
Lats2tm1.1Dupa mutation (1 available); any Lats2 mutation (44 available)
Wwtr1tm1.2Eno mutation (0 available); any Wwtr1 mutation (26 available)
Yap1tm1.1Dupa mutation (2 available); any Yap1 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal bile duct epithelium morphology ( J:223215 )
• slight proliferation of cryokeratin-positive biliary epithelial cells observed in liver following adenovirus expressing Cre recombinase (Ad-Cre) injection; in contrast to overproliferation found in homozygous Lats2tm1.1Dupa Lats1tm1Noj

liver/biliary system
abnormal bile duct epithelium morphology ( J:223215 )
• slight proliferation of cryokeratin-positive biliary epithelial cells observed in liver following adenovirus expressing Cre recombinase (Ad-Cre) injection; in contrast to overproliferation found in homozygous Lats2tm1.1Dupa Lats1tm1Noj
enlarged liver ( J:223215 )
• mice develop slight hepatomegaly 8 weeks after Ad-Cre injection; in contrast to severe hepatomegaly developed by homozygous Lats2tm1.1Dupa Lats1tm1Noj

growth/size/body
enlarged liver ( J:223215 )
• mice develop slight hepatomegaly 8 weeks after Ad-Cre injection; in contrast to severe hepatomegaly developed by homozygous Lats2tm1.1Dupa Lats1tm1Noj




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory