Analysis Tools
mortality/aging
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• mice rarely survive more than 48 hours after birth
• administration of naloxone does not improve lethality
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• Background Sensitivity: most mice die within 24 hours of birth unlike mice on a mixed 129P2/OlaHsd, BALB/c, and C57BL/6 background that survive into adulthood
(J:146754)
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respiratory system
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• Background Sensitivity: under hypercapnic conditions, mice on a congenic C57BL/6 background exhibit reduced breathing frequency compared to similarly treated wild-type mice and unlike mice on a mixed 129P2/OlaHsd, BALB/c, and C57BL/6 background that exhibit a normal response to hypercapnia
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• at birth, mice exhibit irregular respiratory rhythm and frequent apneic episodes unlike wild-type mice
• Background Sensitivity: mice exhibit irregular breathing patterns that are more severe than in mice on a mixed 129P2/OlaHsd, BALB/c, and C57BL/6 background
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nervous system
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• at E19, mice exhibit an increase the number of neurons in the medulla compared to in wild-type medulla
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• irregular breathing pattern suggests defects of the central respiratory rhythm generator
• however, mice exhibit normal heart beats
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• activity at the C4 ventral root is irregular unlike in wild-type mice that is more severe than in homozygotes
• the membrane potential trajectory of the pre-inspiratory neuron activity in the parafacial respiratory group during the pre-inspiratory phase is absent unlike in wild-type mice
• the synchronous inspiratory neuronal activities are weak and the neurons showing synchronous pre-inspiratory neuronal activities are not observed in the parafacial respiratory group unlike in wild-type mice
• the activities of the facial nerve become tonic and lose their synchroneity to the C4 activities unlike in wild-type mice
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