Phenotypes associated with this allele

• Allele Symbol: Cdkn1c^{tm1.1(Cdkn1b*)Kei}
• Allele Name: targeted mutation 1.1, Keiichi I Nakayama
• Allele ID: MGI:3840687
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Cdkn1c^tm1.1(Cdkn1b*)Kei/Cdkn1c^+	B6.129P2-Cdkn1c^tm1.1(Cdkn1b*)Kei	MGI:5294435
ht2	Cdkn1c^tm1.1(Cdkn1b*)Kei/Cdkn1c^+	involves: 129P2/OlaHsd * C57BL/6J	MGI:3840688

Genotype
MGI:5294435

ht1

• Allelic Composition: Cdkn1c^{tm1.1(Cdkn1b*)Kei}/Cdkn1c⁺
• Genetic Background: B6.129P2-Cdkn1c^{tm1.1(Cdkn1b*)Kei}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:176209 )

N • KSL hematopoietic stem cells are normal

Genotype
MGI:3840688

ht2

• Allelic Composition: Cdkn1c^{tm1.1(Cdkn1b*)Kei}/Cdkn1c⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Representative testes, seminal vesicles, and uteri from wild-type, Cdkn1c^tm1Kat/Cdkn1c⁺, and Cdkn1c^{tm1.1(Cdkn1b*)Kei}/Cdkn1c⁺ mice at 7 weeks of age

mortality/aging

mortality/aging ( J:147145 )

N • unlike null mice, all knock in mice survive

cellular

paternal imprinting ( J:147145 )

• all mice carry a maternally inherited mutant allele

growth/size/body

growth/size/body region phenotype ( J:147145 )

N • unlike null mice, knock in mice grow at a rate similar to controls

abnormal abdominal wall morphology ( J:147145 )

• thinning of the abdominal wall or omphalocele are seen

omphalocele ( J:147145 )

• thinning of the abdominal wall or omphalocele are seen

renal/urinary system

abnormal kidney papilla morphology ( J:147145 )

• dysplasia

endocrine/exocrine glands

enlarged adrenal glands ( J:147145 )

• enlargement is less pronounced compared to null mice

reproductive system

uterus atrophy ( J:147145 )

♀ • present in 2 of 9 mice

♀ • incidence is decreased compared to null mice

uterus atresia ( J:147145 )

♀ • present in 3 of 15 mice

♀ • incidence is decreased compared to null mice

embryo

abnormal placenta morphology ( J:147145 )

• dysplasia

digestive/alimentary system

digestive/alimentary phenotype ( J:147145 )

N • cleft palate and shortening of the intestines seen in null mice are largely corrected in knock in mice

vision/eye

vision/eye phenotype ( J:147145 )

N • unlike null mice, knock in mice do not develop cataracts and do not display increased cell proliferation in the lens

skeleton

skeleton phenotype ( J:147145 )

N • rib and vertebral deformities, delayed bone ossification, decreased length of the long bones, and aberrant cell proliferation seen in null mice are largely corrected in knock in mice