Phenotypes associated with this allele

• Allele Symbol: Tcra-J^tm4.1Krg
• Allele Name: targeted mutation 4.1, Michael S Krangel
• Allele ID: MGI:3840777
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tcra-J^tm4.1Krg/Tcra-J^tm4.1Krg	involves: 129S6/SvEvTac	MGI:3840783

Genotype
MGI:3840783

hm1

• Allelic Composition: Tcra-J^tm4.1Krg/Tcra-J^tm4.1Krg
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell receptor alpha chain V-J recombination ( J:147326 )

• use of Jalpha segments 56-58 in recombined Tcra transcripts is 1% of that found in wild-type thymocytes

• use of the Jalpha53 segment is 13% of wild-type and use of the Jalpha52 segment is 33% of wild-type

• the use of Jalpha 50 and other Jalpha segments further downstream is normal

hematopoietic system

abnormal T cell receptor alpha chain V-J recombination ( J:147326 )

• use of Jalpha segments 56-58 in recombined Tcra transcripts is 1% of that found in wild-type thymocytes

• use of the Jalpha53 segment is 13% of wild-type and use of the Jalpha52 segment is 33% of wild-type

• the use of Jalpha 50 and other Jalpha segments further downstream is normal