Phenotypes associated with this allele

• Allele Symbol: Map3k3^tm1Kuro
• Allele Name: targeted mutation 1, Tomohiro Kurosaki
• Allele ID: MGI:3840862
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Map3k3^tm1Kuro/Map3k3^tm1Kuro Tg(Lck-cre)1Jtak/0	involves: C57BL/6	MGI:3840864

Genotype
MGI:3840864

cn1

• Allelic Composition: Map3k3^tm1Kuro/Map3k3^tm1Kuro; Tg(Lck-cre)1Jtak/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased T cell proliferation ( J:147103 )

• T cells exhibit decreased proliferation in response to anti-CD3 stimulation

decreased thymocyte number ( J:147103 )

• the number of thymoyctes is reduced by 40-60% compared to controls

increased double-negative T cell number ( J:147103 )

• the percentage of double-negative thymocytes is about double that of control

decreased double-positive T cell number ( J:147103 )

• the percentage of double-positive thymocytes is reduced by 40-60%

decreased CD4-positive, alpha-beta T cell number ( J:147103 )

• the number of CD4⁺ T cells in the spleen is reduced by about 50% compared to controls

decreased CD8-positive, alpha-beta T cell number ( J:147103 )

• the number of CD8⁺ T cells in the spleen is reduced by about 60% compared to controls

decreased single-positive T cell number ( J:147103 )

• the percentage of single-positive thymocytes is reduced by 40-60%

decreased interferon-gamma secretion ( J:147103 )

• T cells secrete less IFN-gamma in response to anti-CD3 stimulation

decreased interleukin-2 secretion ( J:147103 )

• T cells secrete less IL-2 in response to anti-CD3 stimulation

hematopoietic system

decreased T cell proliferation ( J:147103 )

• T cells exhibit decreased proliferation in response to anti-CD3 stimulation

decreased thymocyte number ( J:147103 )

• the number of thymoyctes is reduced by 40-60% compared to controls

increased double-negative T cell number ( J:147103 )

• the percentage of double-negative thymocytes is about double that of control

decreased double-positive T cell number ( J:147103 )

• the percentage of double-positive thymocytes is reduced by 40-60%

decreased CD4-positive, alpha-beta T cell number ( J:147103 )

• the number of CD4⁺ T cells in the spleen is reduced by about 50% compared to controls

decreased CD8-positive, alpha-beta T cell number ( J:147103 )

• the number of CD8⁺ T cells in the spleen is reduced by about 60% compared to controls

decreased single-positive T cell number ( J:147103 )

• the percentage of single-positive thymocytes is reduced by 40-60%

endocrine/exocrine glands

decreased thymocyte number ( J:147103 )

• the number of thymoyctes is reduced by 40-60% compared to controls

cellular

decreased T cell proliferation ( J:147103 )

• T cells exhibit decreased proliferation in response to anti-CD3 stimulation