All Phenotypes Foxo1<tm1Flv> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Foxo1^tm1Flv/Foxo1^tm1Flv Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0	involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6	MGI:5448154
cn2	Foxo1^tm1Flv/Foxo1^tm1Flv Ifng^tm1Ts/Ifng^tm1Ts Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺	involves: 129S1/Sv * 129S6/SvEvTac * 129S7/SvEvBrd * 129X1/SvJ	MGI:5448156
cn3	Foxo1^tm1Flv/Foxo1^tm1Flv Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ	MGI:5448157
cn4	Foxo1^tm1Flv/Foxo1^tm1Flv Gt(ROSA)26Sor^{tm1(CAG-FOXO1,GFP)Moli}/Gt(ROSA)26Sor⁺ Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6	MGI:5448151
cn5	Foxo1^tm1Flv/Foxo1^tm1Flv Rag1^tm1Mom/Rag1^tm1Mom Tg(Cd4-cre)1Cwi/? Tg(TcraTcrb)425Cbn/?	involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * DBA/2	MGI:3840970
cn6	Foxo1^tm1Flv/Foxo1^tm1Flv Rag1^tm1Mom/Rag1^tm1Mom Tg(CD2-Il7r)1Asin/? Tg(Cd4-cre)1Cwi/? Tg(TcraTcrb)425Cbn/?	involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * DBA/2	MGI:3840971
cn7	Foxo1^tm1Flv/Foxo1^tm1Flv Tg(Cd4-cre)1Cwi/?	involves: 129S6/SvEvTac * C57BL/6 * DBA/2	MGI:3840969

Allelic Composition	Foxo1^tm1Flv/Foxo1^tm1Flv Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0
Genetic Background	involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1^tm1Flv mutation (2 available); any Foxo1 mutation (32 available)
Ndor1^{Tg(UBC-cre/ERT2)1Ejb} mutation (6 available); any Ndor1 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased interferon-gamma secretion ( J:189962 )

• regulatory T cells from tamoxifen-treated mice under the condition of IL12 and IFN-gamma stimulation unlike wild-type cells

• however, production in CD4+ T cells is normal

Allelic Composition	Foxo1^tm1Flv/Foxo1^tm1Flv Ifng^tm1Ts/Ifng^tm1Ts Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * 129S7/SvEvBrd * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1^tm1Flv mutation (2 available); any Foxo1 mutation (32 available)
Foxp3^{tm4(YFP/icre)Ayr} mutation (2 available); any Foxp3 mutation (58 available)
Ifng^tm1Ts mutation (18 available); any Ifng mutation (49 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:189962 )

N	• the lethal inflammatory phenotype is partially rescued

immune system

immune system phenotype ( J:189962 )

N	• regulatory T cells are able to suppress development of colitis in Rag1 null mice receiving naive T cells

increased CD4-positive, alpha-beta T cell number ( J:189962 )

• elevated numbers in the spleen and peripheral lymph nodes are partially rescued compared to in Foxo1^tm1Flv/Foxo1^tm1Flv Foxp3^{tm4(YFP/cre)Ayr}/Foxp3⁺ mice

increased CD8-positive, alpha-beta T cell number ( J:189962 )

• elevated numbers in the spleen and peripheral lymph nodes are partially rescued compared to in Foxo1^tm1Flv/Foxo1^tm1Flv Foxp3^{tm4(YFP/cre)Ayr}/Foxp3⁺ mice

hematopoietic system

increased CD4-positive, alpha-beta T cell number ( J:189962 )

• elevated numbers in the spleen and peripheral lymph nodes are partially rescued compared to in Foxo1^tm1Flv/Foxo1^tm1Flv Foxp3^{tm4(YFP/cre)Ayr}/Foxp3⁺ mice

increased CD8-positive, alpha-beta T cell number ( J:189962 )

• elevated numbers in the spleen and peripheral lymph nodes are partially rescued compared to in Foxo1^tm1Flv/Foxo1^tm1Flv Foxp3^{tm4(YFP/cre)Ayr}/Foxp3⁺ mice

Allelic Composition	Foxo1^tm1Flv/Foxo1^tm1Flv Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:189962 )

• moribund within 35 days of birth

immune system

increased T cell proliferation ( J:189962 )

enlarged spleen ( J:189962 )

increased T cell number ( J:189962 )

• in the spleen and peripheral lymph node

increased CD4-positive, alpha-beta T cell number ( J:189962 )

• in the spleen and peripheral lymph nodes

increased CD8-positive, alpha-beta T cell number ( J:189962 )

• in the spleen and peripheral lymph nodes

increased regulatory T cell number ( J:189962 )

• in peripheral lymph node at day 20

• however, thymic and splenic regulatory T cell numbers are normal at day 12

abnormal regulatory T cell physiology ( J:189962 )

• regulatory T cells are not able to suppress development of colitis in Rag1 null mice receiving na[?]ve T cells unlike wild-type regulatory T cells

enlarged lymph nodes ( J:189962 )

increased interferon-gamma secretion ( J:189962 )

abnormal inflammatory response ( J:189962 )

• infiltrate of leukocytes in the salivary glands, lung interstitia, liver sinusoids, pancreas acini, stomach and colon mucosa

behavior/neurological

hunched posture ( J:189962 )

• lack of mobility associated with hunched posture

paralysis ( J:189962 )

• lack of mobility associated with hunched posture

integument

abnormal skin appearance ( J:189962 )

• crusting of the ears, eyelids and tail

limbs/digits/tail

abnormal tail morphology ( J:189962 )

• scurfy tail

hematopoietic system

increased T cell proliferation ( J:189962 )

enlarged spleen ( J:189962 )

increased T cell number ( J:189962 )

• in the spleen and peripheral lymph node

increased CD4-positive, alpha-beta T cell number ( J:189962 )

• in the spleen and peripheral lymph nodes

increased CD8-positive, alpha-beta T cell number ( J:189962 )

• in the spleen and peripheral lymph nodes

increased regulatory T cell number ( J:189962 )

• in peripheral lymph node at day 20

• however, thymic and splenic regulatory T cell numbers are normal at day 12

abnormal regulatory T cell physiology ( J:189962 )

• regulatory T cells are not able to suppress development of colitis in Rag1 null mice receiving na[?]ve T cells unlike wild-type regulatory T cells

growth/size/body

enlarged spleen ( J:189962 )

cellular

increased T cell proliferation ( J:189962 )

Allelic Composition	Foxo1^tm1Flv/Foxo1^tm1Flv Gt(ROSA)26Sor^{tm1(CAG-FOXO1,GFP)Moli}/Gt(ROSA)26Sor⁺ Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1^tm1Flv mutation (2 available); any Foxo1 mutation (32 available)
Foxp3^{tm4(YFP/icre)Ayr} mutation (2 available); any Foxp3 mutation (58 available)
Gt(ROSA)26Sor^{tm1(CAG-FOXO1,GFP)Moli} mutation (1 available); any Gt(ROSA)26Sor mutation (992 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:189962 )

N	• the lethal inflammatory phenotype is completely rescued

immune system

immune system phenotype ( J:189962 )

N	• the lethal inflammatory phenotype is completely rescued

Allelic Composition	Foxo1^tm1Flv/Foxo1^tm1Flv Rag1^tm1Mom/Rag1^tm1Mom Tg(Cd4-cre)1Cwi/? Tg(TcraTcrb)425Cbn/?
Genetic Background	involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1^tm1Flv mutation (2 available); any Foxo1 mutation (32 available)
Rag1^tm1Mom mutation (49 available); any Rag1 mutation (123 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
Tg(TcraTcrb)425Cbn mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased T cell number ( J:147057 )

• T cell numbers in the spleen and lymph nodes are reduced 80-90% compared to Rag-null OT-II controls

hematopoietic system

decreased T cell number ( J:147057 )

• T cell numbers in the spleen and lymph nodes are reduced 80-90% compared to Rag-null OT-II controls

Allelic Composition	Foxo1^tm1Flv/Foxo1^tm1Flv Rag1^tm1Mom/Rag1^tm1Mom Tg(CD2-Il7r)1Asin/? Tg(Cd4-cre)1Cwi/? Tg(TcraTcrb)425Cbn/?
Genetic Background	involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1^tm1Flv mutation (2 available); any Foxo1 mutation (32 available)
Rag1^tm1Mom mutation (49 available); any Rag1 mutation (123 available)
Tg(CD2-Il7r)1Asin mutation (0 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
Tg(TcraTcrb)425Cbn mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased T cell number ( J:147057 )

• the Il7r transgene rescues the low T cell numbers observed in mice with Foxo1-deficient OT-II T cells

hematopoietic system

decreased T cell number ( J:147057 )

• the Il7r transgene rescues the low T cell numbers observed in mice with Foxo1-deficient OT-II T cells

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to induced colitis ( J:147057 )

• colitis results when mutant bone marrow is used to reconstitute irradiated Rag null mice

• in these bone marrow chimeras, only 7% of CD4⁺ T cells are regulatory T cells compared to 30% in control chimeras

increased single-positive T cell number ( J:147057 )

• there is a slight increase in the number of single-positive Tcr-beta^hi CD4⁺ and CD8⁺ mature thymocytes

abnormal T cell physiology ( J:147057 )

• despite increased proliferation upon activation, T cells have decreased homeostatic proliferation with only a10-20% recovery rate of wild-type in competitive bone marrow chimera assays

abnormal CD4-positive, alpha-beta T cell physiology ( J:147057 )

• a higher percentage of CD4⁺T cells activated in vitro produce IFN-gamma, IL-4, IL-10 or IL-17 compared to controls

abnormal CD8-positive, alpha-beta T cell physiology ( J:147057 )

• a higher percentage of CD8⁺ T cells activated in vitro produce IFN-gamma compared to controls

abnormal T cell activation ( J:147057 )

• an increased percentage of splenic T cells exhibit an activated CD44^hiCD62L^lo or CD69⁺ phenotype

• there is about a 3-fold increase in activated CD4 T cells and a 5- to 10- fold increase in activated CD8 T cells

• a higher percentage of these activated T cells can produce IL-17 or IFN-gamma upon restimulation compared to activated wild-type T cells

increased T cell proliferation ( J:147057 )

• mice have lymphadenopathy resulting from a rapidly proliferating CD4⁺ T cell population

enlarged lymph nodes ( J:147057 )

• mice have lymphadenopathy resulting from a rapidly proliferating CD4⁺ T cell population

increased anti-nuclear antigen antibody level ( J:147057 )

• mice 5-6 months of age have elevated levels of anti-nuclear antigens

increased anti-double stranded DNA antibody level ( J:147057 )

• mice 5-6 months of age have elevated levels of anti-dsDNA antigens

digestive/alimentary system

increased susceptibility to induced colitis ( J:147057 )

• colitis results when mutant bone marrow is used to reconstitute irradiated Rag null mice

• in these bone marrow chimeras, only 7% of CD4⁺ T cells are regulatory T cells compared to 30% in control chimeras

hematopoietic system

increased single-positive T cell number ( J:147057 )

• there is a slight increase in the number of single-positive Tcr-beta^hi CD4⁺ and CD8⁺ mature thymocytes

abnormal T cell physiology ( J:147057 )

• despite increased proliferation upon activation, T cells have decreased homeostatic proliferation with only a10-20% recovery rate of wild-type in competitive bone marrow chimera assays

abnormal CD4-positive, alpha-beta T cell physiology ( J:147057 )

• a higher percentage of CD4⁺T cells activated in vitro produce IFN-gamma, IL-4, IL-10 or IL-17 compared to controls

abnormal CD8-positive, alpha-beta T cell physiology ( J:147057 )

• a higher percentage of CD8⁺ T cells activated in vitro produce IFN-gamma compared to controls

abnormal T cell activation ( J:147057 )

• an increased percentage of splenic T cells exhibit an activated CD44^hiCD62L^lo or CD69⁺ phenotype

• there is about a 3-fold increase in activated CD4 T cells and a 5- to 10- fold increase in activated CD8 T cells

• a higher percentage of these activated T cells can produce IL-17 or IFN-gamma upon restimulation compared to activated wild-type T cells

increased T cell proliferation ( J:147057 )

• mice have lymphadenopathy resulting from a rapidly proliferating CD4⁺ T cell population

cellular

increased T cell proliferation ( J:147057 )

• mice have lymphadenopathy resulting from a rapidly proliferating CD4⁺ T cell population

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