Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(Prrx1-Sox9,-lacZ)1Haak transgene insertion 1, Haruhiko Akiyama MGI:3840957 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E13.5 limb bud morphology is the same as that in null mice that do not express the transgene
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• at E13.5 limb bud morphology is the same as that in null mice that do not express the transgene
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• on the hindlimb digit 1 is present but small
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• the proximal phalanx of hindlimb digit 1 is incomplete
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• pre and post axial polydactyly
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• the proximal phalanx of hindlimb digit 1 is incomplete
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• deformed limbs at birth
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• at E13.5, increased cell density is seen in the anterior and posterior limb bud mesenchyme corresponding to areas of transgene expression and cell proliferation in the posterior mesechyme is increased
• at E14.5 these excess cells aggregate and for an extra postaxial nubbin
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• short and broad digits 1 and 5 on the fore and hind limbs
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• short and broad digits 1 and 5 on the fore and hind limbs
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• a post axial nubbin is present on the hindlimbs
• skeletal preparations show pre and post axial polydactyly
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• after 2 weeks of age mice walk with the backside of their forelimbs facing down towards the ground
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• very short limbs at birth
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• the chondrogenic mesenchymal condensation of the ulna is larger resulting in formation of a short but large cartilage primordia of the ulna
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• delayed endochondral bone formation is seen in the humerus, ulna, radius, and digits 1 and 5 at birth
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• at E13.5, increased cell density is seen in the anterior and posterior limb bud mesenchyme corresponding to areas of transgene expression and cell proliferation in the posterior mesechyme is increased
• at E14.5 these excess cells aggregate and for an extra postaxial nubbin
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• no major abnormalities in limb vascular patterning are detected
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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