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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Prima1tm1Vebe
targeted mutation 1, Veronique Bernard
MGI:3841111
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Prima1tm1Vebe/Prima1tm1Vebe involves: C57BL/6 * DBA/2 MGI:3841124
hm2
 		Prima1tm1Vebe/Prima1tm1Vebe Not Specified MGI:3841129
cx3
 		Achetm4Pata/Achetm4Pata
Prima1tm1Vebe/Prima1tm1Vebe 		involves: 129X1/SvJ * C57BL/6 * DBA/2 MGI:3842461


Genotype
MGI:3841124
hm1
Allelic
Composition		 Prima1tm1Vebe/Prima1tm1Vebe
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prima1tm1Vebe mutation (0 available); any Prima1 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased physiological sensitivity to xenobiotic ( J:147425 )
• mice exhibit enhanced sensitivity to organophosphorus AChE inhibitors compared to in wild-type mice




Genotype
MGI:3841129
hm2
Allelic
Composition		 Prima1tm1Vebe/Prima1tm1Vebe
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prima1tm1Vebe mutation (0 available); any Prima1 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
respiratory system phenotype ( J:147483 )
N
• untreated and bambuterol-treated mice exhibit normal respiration




Genotype
MGI:3842461
cx3
Allelic
Composition		 Achetm4Pata/Achetm4Pata
Prima1tm1Vebe/Prima1tm1Vebe
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Achetm4Pata mutation (0 available); any Ache mutation (30 available)
Prima1tm1Vebe mutation (0 available); any Prima1 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:147425 )
• mice exhibit decreased body weight compared to wild type mice
• however, weight loss can be reduced with a supplemental diet

homeostasis/metabolism
abnormal body temperature homeostasis ( J:147425 )
• mice exhibit postnatal thermoregulation defects




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory