Phenotypes associated with this allele

• Allele Symbol: Tbx18^tm4(cre)Akis
• Allele Name: targeted mutation 4, Andreas Kispert
• Allele ID: MGI:3841145
• Summary: 6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Tbx18^tm1Akis/Tbx18^tm4(cre)Akis	involves: 129S1/SvImJ	MGI:5576975
cn2	Hprt1^tm4(CAG-Tbx18*,-Venus)Akis/Y Gt(ROSA)26Sor^tm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor^+ Tbx18^tm4(cre)Akis/Tbx18^+	involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * NMRI	MGI:5576973
cn3	Hprt1^tm4(CAG-Tbx18*,-Venus)Akis/Y Tbx18^tm4(cre)Akis/Tbx18^+	involves: 129S1/SvImJ * NMRI	MGI:5576974
cn4	Hprt1^tm3(CAG-Tbx18,-Venus)Akis/Y Tbx18^tm4(cre)Akis/Tbx18^+	involves: 129S1/SvImJ * NMRI	MGI:5576972
cn5	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor^+ Tbx18^tm4(cre)Akis/Tbx18^+ Wt1^tm1Jae/Wt1^tm1Jae	involves: 129S4/SvJae	MGI:3841149
cn6	Hprt1^tm1(CAG-Sox9,-EGFP)Akis/Y Tbx18^tm4(cre)Akis/Tbx18^+	involves: 129/Sv * 129S1/SvImJ * NMRI	MGI:4849535

Genotype
MGI:5576975

ht1

• Allelic Composition: Tbx18^tm1Akis/Tbx18^tm4(cre)Akis
• Genetic Background: involves: 129S1/SvImJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:210076 )

N • mice exhibit normal epicardial development at E18.5

Genotype
MGI:5576973

cn2

• Allelic Composition: Hprt1^{tm4(CAG-Tbx18*,-Venus)Akis}/Y; Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺; Tbx18^tm4(cre)Akis/Tbx18⁺
• Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * NMRI

cardiovascular system

abnormal epicardium development ( J:210076 )

♂ • epicardial cells exhibit premature smooth muscle cell differentiation and fail to invade into the right ventricular myocardium unlike in wild-type mice

Genotype
MGI:5576974

cn3

• Allelic Composition: Hprt1^{tm4(CAG-Tbx18*,-Venus)Akis}/Y; Tbx18^tm4(cre)Akis/Tbx18⁺
• Genetic Background: involves: 129S1/SvImJ * NMRI

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:210076 )

♂ • mice die at E14.5

cardiovascular system

cardiovascular system phenotype ( J:210076 )

♂N • cardiomyocytes apoptosis and size are normal

abnormal sinus venosus morphology ( J:210076 )

♂ • sinus horn defects

heart hypoplasia ( J:210076 )

♂

thin ventricle myocardium compact layer ( J:210076 )

♂ • beginning at E12.5 and worsening at E14.5

abnormal pericardium morphology ( J:210076 )

♂

decreased fetal cardiomyocyte proliferation ( J:210076 )

♂ • in the right ventricular myocardium at E12.5 and E13.5

cellular

decreased fetal cardiomyocyte proliferation ( J:210076 )

♂ • in the right ventricular myocardium at E12.5 and E13.5

muscle

thin ventricle myocardium compact layer ( J:210076 )

♂ • beginning at E12.5 and worsening at E14.5

decreased fetal cardiomyocyte proliferation ( J:210076 )

♂ • in the right ventricular myocardium at E12.5 and E13.5

Genotype
MGI:5576972

cn4

• Allelic Composition: Hprt1^{tm3(CAG-Tbx18,-Venus)Akis}/Y; Tbx18^tm4(cre)Akis/Tbx18⁺
• Genetic Background: involves: 129S1/SvImJ * NMRI

mortality/aging

postnatal lethality, complete penetrance ( J:210076 )

♂ • although present in Mendelian ratios at E18.5, mice are not recovered after birth

cardiovascular system

cardiovascular system phenotype ( J:210076 )

♂N • heart morphology is normal at E18.5

Genotype
MGI:3841149

cn5

• Allelic Composition: Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺; Tbx18^tm4(cre)Akis/Tbx18⁺; Wt1^tm1Jae/Wt1^tm1Jae
• Genetic Background: involves: 129S4/SvJae

cardiovascular system

abnormal epicardium development ( J:147421 )

• the formation of the epicardium is severely compromised in E12.5 embryos

Genotype
MGI:4849535

cn6

• Allelic Composition: Hprt1^{tm1(CAG-Sox9,-EGFP)Akis}/Y; Tbx18^tm4(cre)Akis/Tbx18⁺
• Genetic Background: involves: 129/Sv * 129S1/SvImJ * NMRI

renal/urinary system

abnormal ureter morphology ( J:166547 )

♂ • mice exhibit excessive deposition of glycosamiglycans/mucopolysaccharides compared with wild-type mice

♂ • the composition of ureter extracellular matrix is altered compared to in wild-type mice

♂ • however, radial patterning of ureteric mesenchyme is normal

abnormal ureter smooth muscle morphology ( J:166547 )

♂ • mice exhibit disorganized smooth muscle layers in the ureters with round smooth muscle cells