Phenotypes associated with this allele

• Allele Symbol: Bptf^tm1.2Cwu
• Allele Name: targeted mutation 1.2, Carl Wu
• Allele ID: MGI:3841298
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bptf^tm1.2Cwu/Bptf^tm1.2Cwu	involves: 129S1/Sv * C57BL/6	MGI:3841386
ht2	Bptf^Gt(XG023)Byg/Bptf^tm1.2Cwu	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6	MGI:3841385

Genotype
MGI:3841386

hm1

• Allelic Composition: Bptf^tm1.2Cwu/Bptf^tm1.2Cwu
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:147414 )

• embryonic lethality occurs between E7.5 and E8.5

embryo

abnormal ectoderm development ( J:147414 )

• cultured embryoid bodies fail to form more differentiated ectoderm

abnormal endoderm development ( J:147414 )

• cultured embryoid bodies fail to form an endoderm

decreased embryo size ( J:147414 )

• ES cells cultured in vitro from smaller embryoid bodies than controls

absent mesoderm ( J:147414 )

• cultured embryoid bodies fail to form an mesoderm

growth/size/body

decreased embryo size ( J:147414 )

• ES cells cultured in vitro from smaller embryoid bodies than controls

Genotype
MGI:3841385

ht2

• Allelic Composition: Bptf^Gt(XG023)Byg/Bptf^tm1.2Cwu
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:147414 )

• embryonic lethality occurs between E7.5 and E8.5

embryo

embryonic growth arrest ( J:147414 )

• growth of embryonic and extra-embryonic tissues between E5.5 and E7.5 is slow and has defects

• a lack of visceral endoderm suggests embryos arrest development prior to E5.5