Phenotypes associated with this allele

• Allele Symbol: Dag1^tm2.1Kcam
• Allele Name: targeted mutation 2.1, Kevin P Campbell
• Allele ID: MGI:3841383
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Dag1^tm1Kcam/Dag1^tm2.1Kcam Edil3^Tg(Sox2-cre)1Amc/Edil3^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:5470527

Genotype
MGI:5470527

cn1

• Allelic Composition: Dag1^tm1Kcam/Dag1^tm2.1Kcam; Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal axon fasciculation ( J:194150 )

• mice exhibit abnormal formation of the descending hindbrain axonal tract and severe defasciculation of the spinal cord dorsal funiculus compared with wild-type mice

abnormal axon guidance ( J:194150 )

• mice exhibit abnormal formation of the descending hindbrain axonal tract and severe defasciculation of the spinal cord dorsal funiculus compared with wild-type mice

radial glial endfoot detachment ( J:194150 )

• endfoot detachment

abnormal spinal cord ventral commissure morphology ( J:194150 )

• at E11.5, commissural axons exhibit robust postcrossing trajectory defects with failure to project to the lateral portion of the funiculus and altered lateral and ventral funiculi ratio compared with wild-type mice

• at E13, a large number of commissural axons project abnormally within the floor plate unlike in wild-type mice

• at E13.5, mice exhibit extensive disruptions in more lateral aspect of the ventrolateral funiculus compared with wild-type mice

abnormal spinal cord dorsal column morphology ( J:194150 )

• mice exhibit abnormal formation of the descending hindbrain axonal tract and severe defasciculation of the spinal cord dorsal funiculus compared with wild-type mice

cellular

abnormal axon fasciculation ( J:194150 )

• mice exhibit abnormal formation of the descending hindbrain axonal tract and severe defasciculation of the spinal cord dorsal funiculus compared with wild-type mice

abnormal axon guidance ( J:194150 )

• mice exhibit abnormal formation of the descending hindbrain axonal tract and severe defasciculation of the spinal cord dorsal funiculus compared with wild-type mice

radial glial endfoot detachment ( J:194150 )

• endfoot detachment

abnormal basement membrane morphology ( J:194150 )

• at E11.5, mice exhibit progressive fragmentation of the basement membrane surrounding the spinal cord which is accompanied by detachment of radial neuroepithelial endfeet from the basal surface unlike wild-type mice