Phenotypes associated with this allele

• Allele Symbol: Htr2c^tm1Jke
• Allele Name: targeted mutation 1, Joel K Elmquist
• Allele ID: MGI:3841486
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Htr2c^tm1Jke/Y Tg(Pomc1-cre)16Lowl/0	B6.Cg-Htr2c^tm1Jke Tg(Pomc1-cre)16Lowl	MGI:3841490
ot2	Htr2c^tm1Jke/Y	B6.129-Htr2c^tm1Jke	MGI:3841489

Genotype
MGI:3841490

cn1

• Allelic Composition: Htr2c^tm1Jke/Y; Tg(Pomc1-cre)16Lowl/0
• Genetic Background: B6.Cg-Htr2c^tm1Jke Tg(Pomc1-cre)16Lowl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:147514 )

♂ • mice exhibit a decreased survival rate compared to wild-type mice

♂ • mice fed a regular diet exhibit decreased survival compared to mice fed a high fat diet

nervous system

tonic-clonic seizures ( J:147514 )

♂

behavior/neurological

behavior/neurological phenotype ( J:147514 )

♂N • mice exhibit normal food intake and locomotor activity levels

tonic-clonic seizures ( J:147514 )

♂

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:147514 )

♂N • mice exhibit normal leptin levels and anorexigenic responses to d-Fen and metachlorophenylpiperazine

adipose tissue

adipose tissue phenotype ( J:147514 )

♂N • mice exhibit normal adiposity in response to a high fat diet

growth/size/body

growth/size/body region phenotype ( J:147514 )

♂N • mice exhibit normal weight gain in response to a high fat diet

Genotype
MGI:3841489

ot2

• Allelic Composition: Htr2c^tm1Jke/Y
• Genetic Background: B6.129-Htr2c^tm1Jke

mortality/aging

premature death ( J:147514 )

♂ • mice exhibit a decreased survival rate compared to wild-type mice

♂ • mice fed a regular diet exhibit decreased survival compared to mice fed a high fat diet

adipose tissue

increased white adipose tissue amount ( J:147514 )

♂ • when fed a high fat diet, mice exhibit an increase in visceral and subcutaneous depots compared to in similarly wild-type mice

increased percent body fat/body weight ( J:147514 )

♂ • when fed a high fat diet, mice exhibit increased adiposity compared to similarly treated wild-type mice as early as 13 weeks and at 28 weeks

behavior/neurological

impaired behavioral response to xenobiotic ( J:147514 )

♂ • mice treated with d-Fen fail to exhibit reduced food intake as do similarly treated wild-type mice

♂ • mice treated with metachlorophenylpiperazine exhibit a blunted response compared to similarly treated wild-type mice that exhibit a decrease in food intake

polyphagia ( J:147514 )

♂ • mice are hyperphagic compared to wild-type mice

♂ • on a high fat diet, mice exhibit a 50% increase in food intake compared to similarly treated wild-type mice

♂ • meal sizes are larger than for wild-type mice

♂ • however, meal frequency is normal

hyperactivity ( J:147514 )

♂ • when fed a normal diet, mice exhibit hyperactivity compared to wild-type mice without an increase in energy expenditure

tonic-clonic seizures ( J:147514 )

♂

homeostasis/metabolism

increased susceptibility to diet-induced obesity ( J:147514 )

♂ • when fed a high fat diet

increased circulating leptin level ( J:147514 )

♂ • when fed a high fat diet

growth/size/body

decreased lean body mass ( J:147514 )

♂

increased susceptibility to diet-induced obesity ( J:147514 )

♂ • when fed a high fat diet

nervous system

tonic-clonic seizures ( J:147514 )

♂