Phenotypes associated with this allele

• Allele Symbol: Bnip3l^tm1Gwd
• Allele Name: targeted mutation 1, Gerald W Dorn
• Allele ID: MGI:3841600
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Bnip3l^tm1Gwd/Bnip3l^tm1Gwd Nkx2-5^tm1(cre)Rjs/Nkx2-5^+	involves: 129 * 129S7/SvEvBrd	MGI:4430398

Genotype
MGI:4430398

cn1

• Allelic Composition: Bnip3l^tm1Gwd/Bnip3l^tm1Gwd; Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺
• Genetic Background: involves: 129 * 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal heart left ventricle morphology ( J:145086 )

• late after pressure overload, mice exhibit reduced left ventricular end-diastolic diameter, left ventricular dilation, and ventricular remodeling compared with similarly treated wild-type mice

cardiac fibrosis ( J:145086 )

• 9 weeks after pressure overload compared with similarly treated wild-type mice

increased cardiac muscle contractility ( J:145086 )

• late after pressure overload compared with similarly treated wild-type mice

abnormal response of heart to induced stress ( J:145086 )

• late after pressure overload, mice exhibit increased myocardial contractile function and velocity of circumferential shortening and reduced left ventricular end-diastolic diameter, left ventricular dilation, ventricular remodeling, myocardial fibrosis, and cardiomyocyte apoptosis compared with similarly treated wild-type mice

• however, hypertrophic response to pressure overload is normal

homeostasis/metabolism

abnormal response of heart to induced stress ( J:145086 )

• late after pressure overload, mice exhibit increased myocardial contractile function and velocity of circumferential shortening and reduced left ventricular end-diastolic diameter, left ventricular dilation, ventricular remodeling, myocardial fibrosis, and cardiomyocyte apoptosis compared with similarly treated wild-type mice

• however, hypertrophic response to pressure overload is normal

muscle

increased cardiac muscle contractility ( J:145086 )

• late after pressure overload compared with similarly treated wild-type mice

decreased cardiomyocyte apoptosis ( J:145086 )

• 9 weeks after pressure overload compared with similarly treated wild-type mice

cellular

decreased cardiomyocyte apoptosis ( J:145086 )

• 9 weeks after pressure overload compared with similarly treated wild-type mice