Analysis Tools
endocrine/exocrine glands
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• a 1.7 fold increase in alpha cell number per pancreatic area is seen
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• at 3 and 10 weeks of age
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• at 3 weeks of age change in beta cell mass is comparable to decrease in beta cell number
• at 3 weeks of age there is a 20% decrease in the total number of endocrine cells per pancreatic area and a similar decrease is seen at 10 weeks of age
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• increase in the presence of alpha cells within the core and periphery
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• increased secretion at both low and high glucose levels
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• increase in the starting value, ending value, and total response when exocytosis is evoked by a train of depolarizations in isolated beta cells
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homeostasis/metabolism
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• despite hyperglycemia, plasma insulin levels are similar to controls and peripheral insulin resistance is not detected
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• following glucose challenge first phase insulin release is decreased but insulin levels between 5 and 120 minutes post challenge are similar to controls
• about a 3 fold increase in pancreatic glucagon content
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• increased secretion at both low and high glucose levels
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• increase in the starting value, ending value, and total response when exocytosis is evoked by a train of depolarizations in isolated beta cells
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• following ip. glucose challenge
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• males display random hyperglycemia at 4 weeks of age and fasting hyperglycemia by 12 weeks of age
• females display random hyperglycemia at 8 weeks of age
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• increased in both the fasted and random fed states
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• enhanced hepatic conversion of pyruvate into glucose
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