Phenotypes associated with this allele

• Allele Symbol: Flcn^{Gt(RRX115)Byg}
• Allele Name: gene trap RRX115, BayGenomics
• Allele ID: MGI:3842151
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Flcn^Gt(RRX115)Byg/Flcn^Gt(RRX115)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:3842160
ht2	Flcn^Gt(RRX115)Byg/Flcn^+	involves: 129P2/OlaHsd * C57BL/6	MGI:3842159

Genotype
MGI:3842160

hm1

• Allelic Composition: Flcn^{Gt(RRX115)Byg}/Flcn^{Gt(RRX115)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:147582 )

• no homozygous pups result from matings between heterozygotes

embryonic lethality between implantation and somite formation, complete penetrance ( J:173708 )

• no viable homozygotes after E7.5

• 25% of E6.5 embryos are severely abnormal or partially resorbed

embryo

abnormal endoderm development ( J:173708 )

• distorted visceral endoderm and lacking cavitation at E6.5

abnormal egg cylinder morphology ( J:173708 )

• grossly atrophied and disorganized egg cylinders at E6.5

Genotype
MGI:3842159

ht2

• Allelic Composition: Flcn^{Gt(RRX115)Byg}/Flcn⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

renal/urinary system

kidney cyst ( J:147582 )

• 57% of mice at 3-6 months of age have renal cysts consisting of oncocytic cells with an average diameter of 0.4 mm

• a similar incidence of cysts is observed in older mice with an average diameter of 0.8 mm

• solid tumors consisting of oncocytic cells are observed in about 10% of mice

increased kidney tumor incidence ( J:147582 )

• solid tumors consisting of oncocytic cells are observed in the kidneys of about 10% of mice

neoplasm

increased incidence of tumors by chemical induction ( J:147582 )

• mice subjected to ENU-treatment in utero have higher incidence of kidney cysts

• 94% of these mice develop kidney cysts by 5 months of age

• mice average 5.5 cysts per mouse with cysts ranging from 0.1 to 1.9 mm in diameter

• cysts are lined by oncocytic cells

increased lymphoma incidence ( J:147582 )

• is observed in older mice though incidence is similar to what is reported for C57BL/6 mice

increased kidney tumor incidence ( J:147582 )

• solid tumors consisting of oncocytic cells are observed in the kidneys of about 10% of mice

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:147582 )

• mice subjected to ENU-treatment in utero have higher incidence of kidney cysts

• 94% of these mice develop kidney cysts by 5 months of age

• mice average 5.5 cysts per mouse with cysts ranging from 0.1 to 1.9 mm in diameter

• cysts are lined by oncocytic cells

growth/size/body

kidney cyst ( J:147582 )

• 57% of mice at 3-6 months of age have renal cysts consisting of oncocytic cells with an average diameter of 0.4 mm

• a similar incidence of cysts is observed in older mice with an average diameter of 0.8 mm

• solid tumors consisting of oncocytic cells are observed in about 10% of mice