Phenotypes associated with this allele

• Allele Symbol: Tlr4^Lps-2Btlr
• Allele Name: defective lipopolysaccharide response 2 Bruce Beutler
• Allele ID: MGI:3842324
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Tlr4^Lps-2Btlr/Tlr4^+	C57BL/6J-Tlr4^Lps-2Btlr	MGI:3846190
ot2	Tlr4^Lps-2Btlr/?	C57BL/6J-Tlr4^Lps-2Btlr	MGI:3846191

Genotype
MGI:3846190

ht1

• Allelic Composition: Tlr4^Lps-2Btlr/Tlr4⁺
• Genetic Background: C57BL/6J-Tlr4^Lps-2Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased interleukin-1 beta secretion ( J:147339 )

• the index mouse, later genotyped and found to be heterozygous for the mutation, was identified on the basis of reduced interleukin (IL)-1 beta production in response to lipopolysaccharide (LPS)/nigericin

Genotype
MGI:3846191

ot2

• Allelic Composition: Tlr4^Lps-2Btlr/?
• Genetic Background: C57BL/6J-Tlr4^Lps-2Btlr

immune system

decreased tumor necrosis factor secretion ( J:147339 )

• peritoneal macrophages isolated from other G3 progeny of the same lineage as the index mouse, including siblings of the index mouse, are defective in tumor necrosis factor (TNF)-1 alpha production in response to lipopolysaccharide (LPS), a TLR4 ligand

• macrophages from the same mice exhibit a normal TNF-1 alpha response to all other toll-like receptor (TLR) ligands with which they were challenged (MALP-2, TLR2/6; peptidoglycan (PGN), TLR2/6; CpG, TLR9; resiquimod (R-848), TLR7; Pam3CSK4, TLR1/2; poly(I:C), TLR3)