Phenotypes associated with this allele

• Allele Symbol: Pou4f1^tm2.1Nat
• Allele Name: targeted mutation 2.1, Jeremy Nathans
• Allele ID: MGI:3842364
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pou4f1^tm1Nat/Pou4f1^tm2.1Nat Tg(Pax6-cre,GFP)2Pgr/0	involves: 129 * 129S7/SvEvBrd	MGI:3842429

Genotype
MGI:3842429

cn1

• Allelic Composition: Pou4f1^tm1Nat/Pou4f1^tm2.1Nat; Tg(Pax6-cre,GFP)2Pgr/0
• Genetic Background: involves: 129 * 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal retina ganglion cell morphology ( J:147350 )

• the ratio of bistratified:monostratified retinal ganglion cells (RGC) increases from 0.22 in controls to 1.5 in these mice

• there is an absence of RGC dendrites in a narrow stripe of the inner plexiform layer (IPL) that coincides with the boundary between the ON and OFF RGC subtypes

• this gap in RGC dendrites is evident at P4 before the IPL has completely differentiated

vision/eye

abnormal retina ganglion cell morphology ( J:147350 )

• the ratio of bistratified:monostratified retinal ganglion cells (RGC) increases from 0.22 in controls to 1.5 in these mice

• there is an absence of RGC dendrites in a narrow stripe of the inner plexiform layer (IPL) that coincides with the boundary between the ON and OFF RGC subtypes

• this gap in RGC dendrites is evident at P4 before the IPL has completely differentiated