mortality/aging
• die between E6.5 and E7.5
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cellular
• slight increase in apoptosis in embryos at E6.5
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• dramatic reduction in cell proliferation in embryos at E6.5
• unable to establish ES cell lines from E3.5 embryos
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embryo
• slight increase in apoptosis in embryos at E6.5
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• general hypocellularity in embryos at E6.5
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• at E6.5
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growth/size/body
• at E6.5
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