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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kmt5atm1.2Dare
targeted mutation 1.2, Danny Reinberg
MGI:3842473
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Kmt5atm1.2Dare/Kmt5atm1.2Dare involves: 129S1/Sv * C57BL/6 * CBA * SJL MGI:3842508
cn2
 		Kmt5atm1.1Dare/Kmt5atm1.2Dare
Tg(CAG-cre/Esr1*)5Amc/0 		involves: 129S1/Sv * C57BL/6 * CBA * SJL MGI:3842509


Genotype
MGI:3842508
hm1
Allelic
Composition		 Kmt5atm1.2Dare/Kmt5atm1.2Dare
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt5atm1.2Dare mutation (0 available); any Kmt5a mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality before implantation, complete penetrance ( J:147765 )
• although mice are present at E2.5, no mice are detected at E3.5

embryo
failure of zygotic cell division ( J:147765 )
• embryos fail to progress past the 8-cell stage and undergo apoptosis




Genotype
MGI:3842509
cn2
Allelic
Composition		 Kmt5atm1.1Dare/Kmt5atm1.2Dare
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt5atm1.1Dare mutation (0 available); any Kmt5a mutation (48 available)
Kmt5atm1.2Dare mutation (0 available); any Kmt5a mutation (48 available)
Tg(CAG-cre/Esr1*)5Amc mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell physiology ( J:147765 )
• tamoxifen-treated embryonic stem cells exhibit global chromosomal decondensation at interphase compared to in wild-type cells
abnormal cell cycle checkpoint function ( J:147765 )
• tamoxifen-treated embryonic stem cells exhibit a defect in cell growth at G2/M phase unlike wild-type cells
increased apoptosis ( J:147765 )
• 24 hours after tamoxifen treatment, embryonic stem cells undergo apoptosis unlike wild-type cells
abnormal DNA repair ( J:147765 )
• tamoxifen-treated embryonic stem cells exhibit increased DNA damage compared to wild-type cells
decreased DNA replication ( J:147765 )
• tamoxifen-treated embryonic stem cells exhibit decreased DNA synthesis compared to in wild-type cells

homeostasis/metabolism
abnormal DNA repair ( J:147765 )
• tamoxifen-treated embryonic stem cells exhibit increased DNA damage compared to wild-type cells
decreased DNA replication ( J:147765 )
• tamoxifen-treated embryonic stem cells exhibit decreased DNA synthesis compared to in wild-type cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/09/2024
MGI 6.24 		The Jackson Laboratory