Analysis Tools|
Allele Symbol Allele Name Allele ID |
Meg3tm1Kono targeted mutation 1, Tomohiro Kono MGI:3842511 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice survive into adulthood
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• mice weight less than wild-type mice but are intermediate to heterozygous mice when the allele is inherited maternally or paternally
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• when this allele is inherited paternally, only one quarter of expected mice survive to reproduce
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• mice die within 4 weeks regardless of whether the allele is inherited maternally or paternally
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• when this allele is inherited paternally, half of mice born die within a few days after birth
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• when this allele is inherited paternally, the number of mice born is lower than expected
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• more so when this allele is inherited paternally than when it is inherited maternally
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• regardless of whether the allele is inherited maternally or paternally, mice fail to maintain the same growth rate as wild-type mice
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• when this allele is inherited maternally, mice develop hepatocellular necrosis unlike wild-type mice
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• when this allele is inherited maternally, mice develop severely hypoplastic pulmonary alveoli diagnosed by incomplete development of alveolar sacs along with the formation of a thin respiratory epithelium unlike wild-type mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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