Phenotypes associated with this allele

• Allele Symbol: A^tm1Brd
• Allele Name: targeted mutation 1, Allan Bradley
• Allele ID: MGI:3842513
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	A^tm1Brd/A^tm1Brd	C57BL/6N-A^tm1Brd	MGI:3849880
ht2	A^tm1Brd/a	C57BL/6N-A^tm1Brd	MGI:3849879
cx3	A^tm1Brd/A^tm1Brd Ypel4^tm1a(EUCOMM)Wtsi/Ypel4^tm1a(EUCOMM)Wtsi	C57BL/6N-A^tm1Brd Ypel4^tm1a(EUCOMM)Wtsi/WtsiIeg	MGI:7281875

Genotype
MGI:3849880

hm1

• Allelic Composition: A^tm1Brd/A^tm1Brd
• Genetic Background: C57BL/6N-A^tm1Brd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

pigmentation phenotype ( J:149352 )

N • mice homozygous for this targeted reversion to agouti on an otherwise normal C57BL/6N background have uniformly agouti coats, the hairs on both dorsum and ventrum having a subapical yellow band; this differs from the phenotype of a spontaneous revertant of nonagouti that occurred in C57BL/6J, A^w-J, which results in a light- or white-bellied agouti coat

integument

integument phenotype ( J:149352 )

N • mice homozygous for this targeted reversion to agouti on an otherwise normal C57BL/6N background have uniformly agouti coats, the hairs on both dorsum and ventrum having a subapical yellow band; this differs from the phenotype of a spontaneous revertant of nonagouti that occurred in C57BL/6J, A^w-J, which results in a light- or white-bellied agouti coat

Genotype
MGI:3849879

ht2

• Allelic Composition: A^tm1Brd/a
• Genetic Background: C57BL/6N-A^tm1Brd

pigmentation

pigmentation phenotype ( J:149352 )

N • mice heterozygous for this targeted reversion to agouti on an otherwise normal C57BL/6N background have uniformly agouti coats, the hairs on both dorsum and ventrum having a subapical yellow band; this differs from the phenotype of a spontaneous revertant of nonagouti that occurred in C57BL/6J, A^w-J, which results in a light- or white-bellied agouti coat

integument

integument phenotype ( J:149352 )

N • mice heterozygous for this targeted reversion to agouti on an otherwise normal C57BL/6N background have uniformly agouti coats, the hairs on both dorsum and ventrum having a subapical yellow band; this differs from the phenotype of a spontaneous revertant of nonagouti that occurred in C57BL/6J, A^w-J, which results in a light- or white-bellied agouti coat

Genotype
MGI:7281875

cx3

• Allelic Composition: A^tm1Brd/A^tm1Brd; Ypel4^{tm1a(EUCOMM)Wtsi}/Ypel4^{tm1a(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-A^tm1Brd Ypel4^{tm1a(EUCOMM)Wtsi}/WtsiIeg

hematopoietic system

hematopoietic system phenotype ( J:313842 )

N • normal hemoglobin concentration (HGB), red blood cell count (RBC), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), white blood cell count (WBC) and platelet count

N • normal erythropoiesis in bone marrow

N • normal morphology of erythrocyte precursors in bone marrow

N • normal cell cycle of erythrocyte precursors in bone marrow

N • normal enucleation of reticulocytes in bone marrow

N • normal early and late erythroid cell numbers and frequency in spleen

polycythemia ( J:313842 )

• macrocytic secondary polycythemia

increased hematocrit ( J:313842 )

increased mean corpuscular volume ( J:313842 )

abnormal red blood cell deformability ( J:313842 )

• reduced

anisocytosis ( J:313842 )

elliptocytosis ( J:313842 )

macrocytosis ( J:313842 )

reticulocytosis ( J:313842 )

homeostasis/metabolism

increased circulating erythropoietin level ( J:313842 )

immune system

immune system phenotype ( J:313842 )

N • normal spleen weight and early and late erythroid cell numbers and frequency

embryo

embryo phenotype ( J:313842 )

N • mice born at expected Mendelian ratios

mortality/aging

mortality/aging ( J:313842 )

N • viable