Phenotypes associated with this allele

• Allele Symbol: Mif^tm2Gfr
• Allele Name: targeted mutation 2, G Fingerle-Rowson
• Allele ID: MGI:3842525
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mif^tm2Gfr/Mif^tm2Gfr	C57BL/6-Mif^tm2Gfr	MGI:3842542

Genotype
MGI:3842542

hm1

• Allelic Composition: Mif^tm2Gfr/Mif^tm2Gfr
• Genetic Background: C57BL/6-Mif^tm2Gfr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased incidence of tumors by chemical induction ( J:147772 )

• mice treated with benzo[alpha]pyrene-induced develop more skin tumors compared to similarly treated wild-type mice

• benzo[alpha]pyrene-treated mice develop more benign tumors relative to malignant tumors than in similarly treated wild-type mice but not as much as in Mif^tm1Gfr homozygotes

cellular

decreased fibroblast proliferation ( J:147772 )

• mouse embryonic fibroblasts exhibit reduced proliferation compared to wild-type cells that is not as severe as in Mif^tm1Gfr homozygous cells

• malignant mouse embryonic fibroblasts exhibit a modest proliferation defect compared to wild-type cells

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:147772 )

• mice treated with benzo[alpha]pyrene-induced develop more skin tumors compared to similarly treated wild-type mice

• benzo[alpha]pyrene-treated mice develop more benign tumors relative to malignant tumors than in similarly treated wild-type mice but not as much as in Mif^tm1Gfr homozygotes