All Phenotypes Use1<tm1.1Aha> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Use1^tm1.1Aha
targeted mutation 1.1, Akihiro Harada
MGI:3842569

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Use1^tm1.1Aha/Use1^tm1.1Aha	involves: C57BL/6 * SJL	MGI:3842573
cn2	Use1^tm1.1Aha/Use1^tm1.2Aha	involves: BALB/cJ * C57BL/6 * SJL	MGI:3842578
cn3	Use1^tm1.1Aha/Use1^tm1.2Aha Tg(Pcp2-cre)2Mpin/0	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL	MGI:3842577
cn4	Use1^tm1.1Aha/Use1^tm1.1Aha Tg(Nes-cre)1Kln/0	involves: C57BL/6 * SJL	MGI:3842575

Allelic Composition	Use1^tm1.1Aha/Use1^tm1.1Aha
Genetic Background	involves: C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Use1^tm1.1Aha mutation (1 available); any Use1 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:147771 )

• viable with no gross abnormalities

Allelic Composition	Use1^tm1.1Aha/Use1^tm1.2Aha
Genetic Background	involves: BALB/cJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Use1^tm1.1Aha mutation (1 available); any Use1 mutation (18 available)
Use1^tm1.2Aha mutation (1 available); any Use1 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal endoplasmic reticulum morphology ( J:147771 )

• increase in the percentage of MEF cells with vacuolated ER structures and decrease in the percentage of cells with vesiculated ER structures with time following adenoviral cre treatment

increased fibroblast apoptosis ( J:147771 )

• in MEFs after adenoviral cre treatment

increased endoplasmic reticulum stress ( J:147771 )

• expression analysis indicates increased endoplasmic reticulum stress following adenoviral cre treatment

• protein transport from the endoplasmic reticulum to the Golgi complex is impaired

Allelic Composition	Use1^tm1.1Aha/Use1^tm1.2Aha Tg(Pcp2-cre)2Mpin/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Pcp2-cre)2Mpin mutation (1 available)
Use1^tm1.1Aha mutation (1 available); any Use1 mutation (18 available)
Use1^tm1.2Aha mutation (1 available); any Use1 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

ataxia ( J:147771 )

• display cerebellar ataxia after 10 weeks of age

abnormal gait ( J:147771 )

• after 10 weeks of age

nervous system

decreased Purkinje cell number ( J:147771 )

Allelic Composition	Use1^tm1.1Aha/Use1^tm1.1Aha Tg(Nes-cre)1Kln/0
Genetic Background	involves: C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Nes-cre)1Kln mutation (4 available)
Use1^tm1.1Aha mutation (1 available); any Use1 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality ( J:147771 )

nervous system

dilated brain ventricle ( J:147771 )

• dilated ventricles

thin cerebral cortex ( J:147771 )

• decrease in the thickness of the cerebral cortices

abnormal neuron morphology ( J:147771 )

• enlargement of the endoplasmic reticulum is seen

abnormal nervous system physiology ( J:147771 )

• increase in the number of apoptotic cells in the brain at E17.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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