Phenotypes associated with this allele

• Allele Symbol: Cdkn2a^tm3(cre)Cjs
• Allele Name: targeted mutation 3, Charles J Sherr
• Allele ID: MGI:3842628
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Cdkn2a^tm3(cre)Cjs/Cdkn2a^+	involves: 129S1/Sv * C57BL/6	MGI:3842676
cn2	Cdkn2a^tm3(cre)Cjs/Cdkn2a^tm4Cjs	involves: 129S1/Sv * C57BL/6	MGI:3842677
cn3	Cdkn2a^tm3(cre)Cjs/Cdkn2a^tm4Cjs Pdgfrb^tm11Sor/Pdgfrb^tm11Sor	involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6	MGI:3842679

Genotype
MGI:3842676

ht1

• Allelic Composition: Cdkn2a^tm3(cre)Cjs/Cdkn2a⁺
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

male infertility ( J:147752 )

♂ • males are infertile whereas female mutants are fertile

Genotype
MGI:3842677

cn2

• Allelic Composition: Cdkn2a^tm3(cre)Cjs/Cdkn2a^tm4Cjs
• Genetic Background: involves: 129S1/Sv * C57BL/6

vision/eye

abnormal lens morphology ( J:147752 )

• in one animal with monocular total blindness, lens of blind eye was significantly damaged as well as the retina, while lens and neuroretina of other eye were normal

• in an animal with partial bilateral vision loss, less severe accumulation of retrolental cells with focal attachment to the lens was observed with less severe deformation of the retina compared to animals exhibiting complete blindness

microphthalmia ( J:147752 )

• retina/lens lesions collectively contribute to gross anatomic micropthalmia in mutants

abnormal retina morphology ( J:147752 )

• typical lesions observed are aberrant retinal folding, appearance of dysplastic neuroretina detached from pigmented epithelium, and emergence of a fibrotic retrolental mass containing pigmented cells that erodes the posterior lens

• severity of anatomical defects correlates with functional impairment

retina fold ( J:147752 )

• aberrant retinal folding

blindness ( J:147752 )

• at 5 months of age, animals display varying ocular defects with some animals being totally blind or having partial bilateral vision impairment and some having normal vision;

Genotype
MGI:3842679

cn3

• Allelic Composition: Cdkn2a^tm3(cre)Cjs/Cdkn2a^tm4Cjs; Pdgfrb^tm11Sor/Pdgfrb^tm11Sor
• Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

vision/eye

vision/eye phenotype ( J:147752 )

N • at 3 months of age, all mutants have normal visual acuity

N • no retinal pathology is evident and vitreous is clear

N • normal vision is in contrast to Cdnk2a compound heterozygotes not carrying the floxed Pdgfr allele which show significantly compromised visual acuity