Phenotypes associated with this allele

• Allele Symbol: Il27^tm1Cua
• Allele Name: targeted mutation 1, Daniel J Cua
• Allele ID: MGI:3842663
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il27^tm1Cua/Il27^tm1Cua	C57BL/6-Il27^tm1Cua	MGI:3842674

Genotype
MGI:3842674

hm1

• Allelic Composition: Il27^tm1Cua/Il27^tm1Cua
• Genetic Background: C57BL/6-Il27^tm1Cua

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal CD4-positive T cell differentiation ( J:147706 )

• more CD4⁺ T cells develop into Th17 cells expressing IL-17A when mice are put into a delayed-type hypersensitivity model and an experimental autoimmune encephalomyelitis model

increased susceptibility to type IV hypersensitivity reaction ( J:147706 )

• mice have an exaggerated DTH response in a model where wild-type OT-II T cells are transferred into the mice prior to immunization with OVA peptide

• these mice have significantly higher footpad swelling than controls after OVA administration

• there is also a 30% increase in the number of OT-II T cells producing IL-17A in this model compared to controls

increased susceptibility to experimental autoimmune encephalomyelitis ( J:147706 )

• mice develop a higher mean disease score after immunization with MOG peptide compared to controls (3.6 vs. 3.1)

• the number of T cells producing IL-17A is increased in the central nervous system compared to controls

hematopoietic system

abnormal CD4-positive T cell differentiation ( J:147706 )

• more CD4⁺ T cells develop into Th17 cells expressing IL-17A when mice are put into a delayed-type hypersensitivity model and an experimental autoimmune encephalomyelitis model